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Clinical trialNCT07115953RecruitingInterventional

Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension

SponsorMedtronic VascularEnrollment130Cardiovascular DiseasesChronic Kidney DiseasesDiabetes MellitusHypertensionVascular Diseases
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of the SPYRAL SWYFT sub-study is to evaluate whether renal denervation with the Symplicity Spyral system performed in the main and first order branch renal arteries yields a shorter procedure time and is as effective in reducing blood pressure than the procedural approach used in the SPYRAL HTN-ON MED and SPYRAL PIVOTAL - SPYRAL HTN-OFF MED clinical studies in an uncontrolled hypertensive population.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

21 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • the Alfred Hospital

    Melbourne, Australia

    Tony Walton, MD
    Recruiting
  • Royal Perth Hospital

    Perth, Australia

    Markus Schlaich, MD
    Recruiting
Belgium
  • Ziekenhuis Oost Limburg

    Genk, Limburg, Belgium

    Koen Ameloot, MD
    Recruiting
  • Chc Montlégia

    Liège, Liège, Belgium

    Pieter-Jan Palmers, MD
    Recruiting
  • Algemeen Stedelijk Ziekenhuis - Campus Aalst

    Aalst, Belgium

    Jan Debrauwere, MD
    Recruiting
  • Az Sint Jan Brugge-Oostende Av

    Bruges, Belgium

    Jan Van Der Hyden, MD
    Recruiting
  • Universitair Ziekenhuis Gent

    Ghent, Belgium

    Benny Drieghe, MD
    Recruiting
Germany
  • Universitat Des Saarlandes

    Homburg, Saarland, Germany

    Michael Böhm, MD
    Recruiting
  • Sana Kliniken Lübeck Gmbh

    Lübeck, Schleswig-Holstein, Germany

    Joachim Weil, MD
    Recruiting
  • Universitätsklinikum Erlangen

    Erlangen, Germany

    Roland Schmeider, MD
    Recruiting
  • Leipzig Heart Institute

    Leipzig, Germany

    Karl Fenger, MD
    Recruiting
  • Schwarzwald-Baar Klinikum Villingen-Schwenningen

    Villingen-Schwenningen, Germany

    Sebastian Ewen, Prof. Dr.
    Recruiting
Greece
  • Hippokration General Hospital of Athens

    Athens, Greece

    Konstantinos Tsioufis, Prof Dr
    Recruiting
Ireland
  • Mater Misericordiae University Hospital

    Dublin, Dublin, Ireland

    Terminated
Malaysia
  • Sarawak Heart Center

    Kota, Malaysia

    Ong Tiong Kiam
    Recruiting
  • Institut Jantung Negara - National Heart Institute

    Kuala Lumpur, Malaysia

    Amin Ariff Nuruddin, Dr
    Recruiting
Netherlands
  • Zuyderland Medisch Centrum Heerlen

    Heerlen, Netherlands

    Saman Rasoul, MD
    Recruiting
  • Erasmus University Medical Center

    Rotterdam, Netherlands

    Joost Daemen, MD, PhD
    Recruiting
Taiwan
  • Mackay Memorial Hospital, Tamsui Branch

    Taipei, Taiwan

    Ying-Hsiang Lee, Dr.
    Recruiting
  • National Taiwan University Hospital

    Taipei, Taiwan

    Tzung-Dau Wang, Prof. Dr.
    Recruiting
United Kingdom
  • Oxford University Hospitals Nhs Trust - John Radcliffe Hospital

    Oxford, United Kingdom

    Giovanni Luigi De Maria
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
22 Sept 2025
Primary completion
30 Jun 2027
Completion
31 Dec 2029
Last update posted
30 Jun 2026
Registered enrollment
130
Registry id
NCT07115953
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.