Clinical trialNCT07157774RecruitingPhase 3Interventional

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

SponsorEli Lilly and CompanyEnrollment10,450Atherosclerotic Cardiovascular Disease (ASCVD)Elevated Lp(a)

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

801 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Cec - Consultorios de Especialidades Cardiovasculares
Bahía Blanca, Argentina
Veronica Heredia
Recruiting
Buenos Aires Macula S.A
Buenos Aires, Argentina
Augusto Lavalle Cobo
Recruiting
Cemedic
Buenos Aires, Argentina
Claudio Majul
Recruiting
Ciprec
Buenos Aires, Argentina
Fernando Guerlloy
Recruiting
Ciprec
Buenos Aires, Argentina
Angela Romero Zarante
Recruiting
Conexa Investigacion Clinica S.A.
Buenos Aires, Argentina
María Scioscia
Recruiting
Cardiología Palermo
Buenos Aires, Argentina
Paula Perez Terns
Recruiting
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Buenos Aires, Argentina
Emilio Alaguibe
Recruiting
Centro Médico Arsema
Buenos Aires, Argentina
Marcelo casas
Recruiting
Centro de Investigaciones Metabólicas (cinme)
Buenos Aires, Argentina
Juan Herrera Paz
Recruiting
Cicemo Srl
Buenos Aires, Argentina
Pablo Costanzo
Recruiting
Consultorio Medico Dr Litvak Bruno
Buenos Aires, Argentina
MARCOS LITVAK BRUNO
Recruiting
Consultorio Medico Investigador Principal Dr Besada
Buenos Aires, Argentina
Diego Besada
Recruiting
Fundación Respirar
Buenos Aires, Argentina
Marina Uhrig
Recruiting
Glenny Corp. S.A.
Buenos Aires, Argentina
Martin Koretzky
Recruiting
Instituto Médico Especializado (ime)
Buenos Aires, Argentina
Gabriela Rossi
Recruiting
Investigaciones Medicas Imoba Srl
Buenos Aires, Argentina
Jose Soler
Recruiting
Kynet
Buenos Aires, Argentina
Adrian Proietti
Recruiting
Mautalen Salud E Investigación
Buenos Aires, Argentina
Daniel Chirino Navarta
Recruiting
Stat Research S.A.
Buenos Aires, Argentina
Lucas Gutnisky
Recruiting
Cemediab
C.a.b.a., Argentina
Alejandro Chertkoff
Recruiting
Idim - Instituto de Investigaciones Metabólicas
Ciudad de Buenos Aires, Argentina
Mariela Bazan
Recruiting
Instituto de Cardiología "juana F. Cabral"
Corrientes, Argentina
Julio Vallejos
Recruiting
Centro Medico Privado San Vicente Diabetes
Córdoba, Argentina
Cecilia Luquez
Recruiting
Centro Médico Colón
Córdoba, Argentina
Maria Parody
Recruiting
Instituto de Investigaciones Clínicas Córdoba
Córdoba, Argentina
Mauro Pautasso
Recruiting
Cipadi - Centro Integral de Prevencion Y Atencion En Diabetes
Godoy Cruz, Argentina
Pedro Rosario Fabian Calella
Recruiting
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, Argentina
Juan Dominguez
Recruiting
Cmd-Centro Médico Y Diagnóstico Por Imágenes
Junín, Argentina
Maria Pelagagge
Recruiting
Cimel
Lanus, Argentina
Ana Comes
Recruiting
Polo de Salud Vistalba
Lujan de Cuyo, Argentina
Sergio Ciccarelli
Recruiting
Centro de Investigaciones Médicas Mar del Plata
Mar del Plata, Argentina
Alejandro Pereyra
Recruiting
Instituto de Investigaciones Clínicas Mar del Plata
Mar del Plata, Argentina
Sergio Nemi
Recruiting
Fundacion Scherbovsky
Mendoza, Argentina
Eduardo Perez Herranz
Recruiting
Instituto de Cardiología Wolff
Mendoza, Argentina
SEBASTIAN WOLFF
Recruiting
Instituto de Investigaciones Clinicas Quilmes
Quilmes, Argentina
Adrian Hrabar
Recruiting
Dim Clínica Privada
Ramos Mejía, Argentina
Oscar Montaña
Recruiting
Centro Rosarino de Investigaciones Clinicas (crics)
Rosario, Argentina
Josefina Chirife
Recruiting
Fundacion Estudios Clinicos
Rosario, Argentina
María Schiavoni
Recruiting
Hospital Provincial del Centenario
Rosario, Argentina
Martin Najenson
Recruiting

761 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

MuvalaplinPlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 2 Sept 2025
Primary completion: 31 Mar 2031
Completion: 31 Mar 2031
Last update posted: 21 Aug 2026
Registered enrollment: 10,450
Registry id: NCT07157774

Cross-registrations

EU-CTR / CTIS (EudraCT)2025-521067-13-00

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.