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Clinical trialNCT07164313RecruitingPhase 1Interventional

A Study of ZW251 in Participants With Advanced Solid Tumors

SponsorZymeworks BC Inc.Enrollment100Germ Cell TumorHepatocellular CarcinomaSquamous Cell Non-Small Cell Lung Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to find out if ZW251, an antibody-drug conjugate targeting glypican-3 (GPC3), is safe and can treat participants with advanced cancers, including hepatocellular carcinoma (HCC), squamous cell non-small cell lung cancer (NSCLC), or germ cell tumors (GCT).

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

25 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Ireland
  • Start - Dublin Mater Misericordiae University Hospital (mmuh)

    Dublin, Ireland

    Austin Duffy, MD, DMed
    Recruiting
Japan
  • National Cancer Center East

    Kashiwa, Japan

    Masafumi Ikeda, MD, PhD
    Recruiting
  • Kyoto University Hospital

    Kyoto, Japan

    Takako Nakajima, MD
    Recruiting
  • Kansai Medical University Hospital

    Osaka, Japan

    Toshio Shimizu, MD, PhD
    Recruiting
  • National Cancer Center Hospital

    Tokyo, Japan

    Yuta Maruki, MD
    Recruiting
Portugal
  • Start Lisboa A - Unidade de Ensaios Clãnicos - Hospital de Santa Maria

    Lisbon, Portugal

    Andre Mansinho, MD, MSc
    Recruiting
  • Unidade Local de Saúde Gaia E Espinho

    Vila Nova de Gaia, Portugal

    Andreia Capela, MD
    Recruiting
Spain
  • Hospital Universitario Vall D'Hebron

    Barcelona, Spain

    Jaume Capdevila Castillon, MD, PhD
    Recruiting
  • Start Barcelona

    Barcelona, Spain

    Tatiana Hernandez Guerrero, MD, PhD
    Recruiting
  • Start - Rioja Hospital Universitario San Pedro

    Logroño, Spain

    Maria Jose de Miguel Luken, MD
    Recruiting
  • Next Oncology Madrid

    Madrid, Spain

    Valentina Boni, MD, PhD
    Recruiting
  • Start Madrid Hospital Universitario Fundacion Jimenez Diaz

    Madrid, Spain

    Manuel Pedregal Trujillo, MD
    Recruiting
  • Start Madrid Hospital Universitario Hm Sanchinarro - Ciocc

    Madrid, Spain

    Emiliano Calvo, MD, PhD
    Recruiting
  • Hospital Universitario Virgen de la Victoria

    Málaga, Spain

    Javier Garcia Corbacho, MD
    Recruiting
  • Clinica Universidad de Navarra

    Pamplona, Spain

    Bruno Sangro, MD, PhD
    Recruiting
Taiwan
  • National Taiwan University Hospital

    Taipei, Taiwan

    Ann Lii Cheng, MD
    Recruiting
  • Taipei Veterans General Hospital

    Taipei, Taiwan

    Yi-Hsiang Huang, MD, PhD
    Recruiting
United States
  • Ucsf Comprehensive Cancer Center

    San Francisco, California, United States

    Katie Kelley, MD
    Recruiting
  • University of California Los Angeles - Cancer Care - Santa Monica (ucla)

    Santa Monica, California, United States

    Richard Finn, MD
    Recruiting
  • Norton Cancer Institute

    Louisville, Kentucky, United States

    John Hamm, MD FACP, FASCO
    Recruiting
  • Start Midwest

    Grand Rapids, Michigan, United States

    Sreenivasa Chandana, MD, PhD
    Recruiting
  • Hackensack University Medical Center

    Hackensack, New Jersey, United States

    Martin Gutierrez, MD
    Recruiting
  • Memorial Sloan Kettering Cancer Center

    New York, New York, United States

    Ghassan Abou-Alfa, MD, JD, MBA, PhD
    Recruiting
  • Md Anderson Cancer Center

    Houston, Texas, United States

    Ecaterina Dumbrava, MD
    Recruiting
  • Start San Antonio

    San Antonio, Texas, United States

    Muralidhar Beeram, MD, MBBS
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

ZW251
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
21 Oct 2025
Primary completion
30 Sept 2027
Completion
31 May 2028
Last update posted
7 May 2026
Registered enrollment
100
Registry id
NCT07164313

Cross-registrations

EU-CTR / CTIS (EudraCT)2025-523088-39

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.