Clinical trialNCT07199192Not, yet, recruitingPhase 4Interventional

Steroid Treatment for Severe Acute Respiratory Infection (STAR) Trial

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment3,000HypoxemiaSevere Acute Respiratory Syndrome

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Multicenter, parallel-group, randomized clinical trial comparing the administration of systemic corticosteroids at a dose equivalent to 40 mg of prednisolone per day for 7 days vs no corticosteroid administration among adults hospitalized with severe acute respiratory infection and hypoxemia.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jane O'Halloran, MD, PhD
Washington Univeristy School of Medicine (ID-CRU)
Principal Investigator
clinicaltrials.gov ↗
Matthew W Semler, MD
Vanderbilt University Medical Center
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Minnesota
Minneapolis, Minnesota, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Corticosteroid →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Mar 2026
Primary completion: 1 Dec 2028
Completion: 1 Dec 2028
Last update posted: 19 Feb 2026
Registered enrollment: 3,000
Registry id: NCT07199192

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.