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Clinical trialNCT07205887RecruitingPhase 2Interventional

A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO

SponsorEyeBiotech Ltd.Enrollment160Branch Retinal Vein Occlusion (BRVO)Neovascular Age-Related Macular Degeneration (NVAMD)
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

EYE-RES-104 is a randomized, dose-masked study of intravitreal remigromig (EYE103) in participants with neovascular age-related macular degeneration (NVAMD) or macular edema following branch retinal vein occlusion (BRVO). The study will consist of 4 patient cohorts, with participants in each cohort randomized (1:1) to either a low dose of remigromig via IVT or a high dose of remigromig via IVT. 40 participants will be enrolled in each cohort. Enrollment timing for each cohort will be sequenced into specific arms of the study at the Sponsor's discretion. All participants in the study will receive a total of 3 injections of remigromig into the study eye, spaced at 4 weeks apart. All participants will return at designated time points following each injection for safety and efficacy assessments. The Week 12 Visit will serve as the end of study visit for all participants.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

55 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Scottsdale, Az

    Scottsdale, Arizona, United States

    Recruiting
  • Scottsdale, Arizona

    Scottsdale, Arizona, United States

    Recruiting
  • Glendale, Ca

    Glendale, California, United States

    Recruiting
  • Glendale, California

    Glendale, California, United States

    Recruiting
  • Modesto, California

    Modesto, California, United States

    Recruiting
  • Mountain View, California

    Mountain View, California, United States

    Recruiting
  • Sacramento, Ca

    Sacramento, California, United States

    Recruiting
  • Sacramento, California

    Sacramento, California, United States

    Recruiting
  • Sactamento, California

    Sacramento, California, United States

    Recruiting
  • Santa Ana, California

    Santa Ana, California, United States

    Recruiting
  • Rsc Research Llc

    Denver, Colorado, United States

    Recruiting
  • Fort Lauderdale, Fl

    Fort Lauderdale, Florida, United States

    Recruiting
  • Fort Lauderdale, Florida

    Fort Lauderdale, Florida, United States

    Recruiting
  • Florida Retina Institute

    Jacksonville, Florida, United States

    Recruiting
  • Florida Retina Institute

    Orlando, Florida, United States

    Recruiting
  • Lemont, Il

    Lemont, Illinois, United States

    Recruiting
  • Lemont, Illinois

    Lemont, Illinois, United States

    Recruiting
  • Hagerstown, Md

    Hagerstown, Maryland, United States

    Recruiting
  • Hagerstown, Maryland

    Hagerstown, Maryland, United States

    Recruiting
  • Madison, Ms

    Madison, Mississippi, United States

    Recruiting
  • Madison, Mississippi

    Madison, Mississippi, United States

    Recruiting
  • Bloomfield, Nj

    Bloomfield, New Jersey, United States

    Recruiting
  • Bloomfield, New Jersey

    Bloomfield, New Jersey, United States

    Recruiting
  • Long Island Vitreoretinal Consultants of Ny

    Great Neck, New York, United States

    Recruiting
  • Asheville, North Carolina

    Asheville, North Carolina, United States

    Recruiting
  • Cary, North Carolina

    Cary, North Carolina, United States

    Recruiting
  • North Carolina Retina Associates

    Greenville, North Carolina, United States

    Recruiting
  • Wake Forest, Nc

    Wake Forest, North Carolina, United States

    Recruiting
  • Wake Forest, North Carolina

    Wake Forest, North Carolina, United States

    Recruiting
  • West Columbia, Sc

    West Columbia, South Carolina, United States

    Recruiting
  • West Columbia, South Carolina

    West Columbia, South Carolina, United States

    Recruiting
  • Germantown, Tennessee

    Germantown, Tennessee, United States

    Recruiting
  • Knoxville, Tennessee

    Knoxville, Tennessee, United States

    Recruiting
  • Nashville, Tn

    Nashville, Tennessee, United States

    Recruiting
  • Nashville, Tennessee

    Nashville, Tennessee, United States

    Recruiting
  • Abilene, Texas

    Abilene, Texas, United States

    Recruiting
  • Amarillo, Texas

    Amarillo, Texas, United States

    Recruiting
  • Austin, Tx

    Austin, Texas, United States

    Recruiting
  • Austin, Texas

    Austin, Texas, United States

    Recruiting
  • Bellaire, Tx

    Bellaire, Texas, United States

    Recruiting
15 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Aflibercept 2.0 mgRemigromig
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
12 Sept 2025
Primary completion
30 Jun 2028
Completion
30 Jun 2028
Last update posted
20 Oct 2026
Registered enrollment
160
Registry id
NCT07205887
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.