Clinical trialNCT07209397RecruitingInterventional

Detrusor Nerve Radiofrequency Ablation for Overactive Bladder in Women

SponsorInMode MD Ltd.Enrollment202Idiopathic Overactive BladderIdiopathic Overactive Bladder With Urinary IncontinenceMixed Urinary IncontinenceMixed Urinary Incontinence (Urge-Predominant)Overactive BladderOveractive Bladder (OAB)+1 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this clinical trial is to learn if a vaginal radiofrequency (RF) device called MORPHEUSV works to treat overactive bladder (OAB) in women. Researchers also want to learn how safe the device is for this indication. This study will include women ages 22 to 80 who have had OAB symptoms for at least 6 months. The main questions it aims to answer are: Does the MORPHEUSV device lower the number of daily episodes of accidental urine leakage caused by urgency? Does it work better than a sham (placebo) treatment? Researchers will compare the MORPHEUSV device to a sham treatment to see how well it reduces symptoms of overactive bladder. Participants will: 1) Receive one session of either the MORPHEUSV or sham treatment. 2) Track their symptoms using a diary and questionnaires 3) Return for three to six follow-up visits over 12 months. This study is being conducted at multiple clinics in the United States.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Mickey Karram, MD
Foundation for Female Health Awareness
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Stanford Medicine Department of Obstetrics & Gynecology
Palo Alto, California, United States
Eric Sokol, MD
Not, yet, recruiting
Medstar Health Research Institute
Washington D.C., District of Columbia, United States
Alexis Dieter, MDCheryl Iglesia, MD
Not, yet, recruiting
Advanced Specialty Research
Boise, Idaho, United States
Bill Laitinen, MD
Recruiting
University of Chicago Medicine Urogynecology
Chicago, Illinois, United States
Christina Lewicky-Gaupp, MDDouglas Russo, MDIris Burgard, MDJuraj Letko, MDKimberly Kenton, MDMargaret Mueller, MDSarah Collins, MD
Not, yet, recruiting
Cypress Medical Research Center
Wichita, Kansas, United States
Kevin Miller, MD
Recruiting
Bay State Clinical Trials
Watertown, Massachusetts, United States
Henry Mitcheson, MD
Recruiting
Urology Center, P.C.
Omaha, Nebraska, United States
Emily Kean-Puccioni, MD
Recruiting
Unlv Kirk Kerkorian School of Medicine Department of Gynecologic Surgery & Obstetrics
Las Vegas, Nevada, United States
Nadia Gomez, MDYarini Quezada, MD
Not, yet, recruiting
Atrium Health Wake Forest Female Pelvic Health Division
Winston-Salem, North Carolina, United States
Amr Sherif El Haraki, MDCatherine Matthews, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 25 Nov 2025
Primary completion: 30 Jun 2027
Completion: 30 Nov 2027
Last update posted: 30 Jan 2026
Registered enrollment: 202
Registry id: NCT07209397

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.