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Clinical trialNCT07217249Enrolling, by, invitationInterventional

Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years

SponsorCase Western Reserve UniversityEnrollment570Corneal Endothelial DecompensationFuchs Endothelial Corneal Dystrophy
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This multi-center clinical trial is designed to assess the association of diabetes in a cornea donor with transplant success and loss of endothelial cells 5 years following Descemet membrane endothelial keratoplasty (DMEK). Study eyes are assigned to receive either a cornea from a donor without diabetes or a cornea from a donor with diabetes in a masked fashion.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

14 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Georgia Eye Partners

    Atlanta, Georgia, United States

  • Price Vision Group

    Indianapolis, Indiana, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, United States

  • Kansas City Eye Clinic

    Overland Park, Kansas, United States

  • Mid-Atlantic Cornea Consultants

    Baltimore, Maryland, United States

  • the Wilmer Eye Institute/johns Hopkins

    Baltimore, Maryland, United States

  • University of Michigan/kellogg Eye Center

    Ann Arbor, Michigan, United States

  • Verdier Eye Center

    Grand Rapids, Michigan, United States

  • Minnesota Eye Consultants

    Bloomington, Minnesota, United States

  • Mayo Clinic

    Rochester, Minnesota, United States

  • Associated Eye Care

    Stillwater, Minnesota, United States

  • Moyes Eye Center

    Kansas City, Missouri, United States

  • Legacy Devers Eye Institute

    Portland, Oregon, United States

  • Ophthalmic Partners

    Bala-Cynwyd, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
3 Dec 2025
Primary completion
30 Dec 2029
Completion
30 Apr 2030
Last update posted
27 Feb 2026
Registered enrollment
570
Registry id
NCT07217249
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.