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Clinical trialNCT07225387RecruitingPhase 4Interventional

Safety and Efficacy of Combination Belimumab and Voclosporin in the Treatment of Proliferative Forms of Lupus Glomerulopathy: Synergy Trial

SponsorNephroNet, Inc.Enrollment30Lupus Nephritis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a Phase IV, open-label, randomized trial to determine whether the combination of Belimumab (BEL) and Voclosporin (VCS), plus background therapy with Mycophenolate Mofetil (MMF), improves the proportion of patients with proliferative lupus nephritis achieving complete renal response (CRR) compared to proportion of patients achieving CRR from recent clinical trials. This protocol will additionally determine whether combination therapy using Belimumab (BEL) and Voclosporin (VCS) facilitates rapid discontinuation of MMF.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Aara Clinical Research

    Glendale, Arizona, United States

    Eric Peters, MD
    Recruiting
  • Piedmont Physicians Rheumatology

    Atlanta, Georgia, United States

    Wambui Machua, MD
    Recruiting
  • Georgia Nephrology Research Institute

    Lawrenceville, Georgia, United States

    James A Tumlin, MD
    Recruiting
  • Parris & Associates

    Lawrenceville, Georgia, United States

    Glen Parris, MD
    Recruiting
  • Nephrology Clinical Trials Unit the Ohio State University Wexner Medical Center

    Columbus, Ohio, United States

    Isabelle Ayoub, MD
    Recruiting
  • Oklahoma Medical Research Foundation

    Oklahoma City, Oklahoma, United States

    Christina Arriens, MD
    Recruiting
  • Aara Clinical Research

    Fort Worth, Texas, United States

    Shariq Chudhri, DO
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Voclosporin →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
1 Oct 2024
Primary completion
31 Jan 2027
Completion
31 Jan 2027
Last update posted
6 Nov 2025
Registered enrollment
30
Registry id
NCT07225387
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.