Clinical trialNCT07226232RecruitingPhase 3Interventional

Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

SponsorVA Office of Research and DevelopmentEnrollment240Major Depression

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S. military Veterans with and without (±) concurrent posttraumatic stress disorder.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Lori Lynne Davis, MD AB
Birmingham VA Medical Center, Birmingham, AL
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Birmingham Va Medical Center, Birmingham, Al
Birmingham, Alabama, United States
Lori Lynne Davis, MD AB
Recruiting
Tuscaloosa Va Medical Center, Tuscaloosa, Al
Tuscaloosa, Alabama, United States
Recruiting
Va Portland Health Care System, Portland, Or
Portland, Oregon, United States
Recruiting
Corporal Michael J. Crescenz Va Medical Center, Philadelphia, Pa
Philadelphia, Pennsylvania, United States
Recruiting
Va Puget Sound Health Care System Seattle Division, Seattle, Wa
Seattle, Washington, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Psilocybin

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Aug 2026
Primary completion: 2 Dec 2030
Completion: 30 Jun 2031
Last update posted: 14 Aug 2026
Registered enrollment: 240
Registry id: NCT07226232

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.