findmyKOL
Clinical trialNCT07226895RecruitingPhase 1/PHASE2Interventional

A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

SponsorMonument Therapeutics LimitedEnrollment150Clinical High Risk for Psychosis (CHR)
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this clinical trial is to learn how tests undertaken by people at high risk of developing psychosis (aged 17 to 30 years old) change when those people are given the study drug MT1988 daily for 8 weeks. This will help identify tests that could be used in later trials developing treatments for symptoms in people at high risk of developing psychosis, to measure whether those new treatments are effective. The main question this trial aims to answer is: Can any of the tests (biomarkers) used in this study detect changes in participants dosed with one of two different dose levels of MT1988? Researchers will compare the results from two dose levels of MT1988 to a placebo group. Researchers do not expect to see the test results change in participants taking placebo and this will be compared to changes expected in test results in participants taking MT1988. Participants will: * take a dose of MT1988 or placebo twice per day for 8 weeks * attend clinic appointments every two weeks to undertake assessments * report any side effects they experience to the researchers

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

15 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of California, Irvine

    Irvine, California, United States

    Recruiting
  • University of California

    Los Angeles, California, United States

    Recruiting
  • University of California, San Francisco

    San Francisco, California, United States

    Recruiting
  • Yale University Conneticut Mental Health Center

    New Haven, Connecticut, United States

    Recruiting
  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, United States

    Recruiting
  • Washington University

    St Louis, Missouri, United States

    Recruiting
  • Northwell Health

    Glen Oaks, New York, United States

    Recruiting
  • Columbia University

    New York, New York, United States

    Recruiting
  • Icahan School of Medicine at Mount Sinai

    New York, New York, United States

    Recruiting
  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, United States

    Recruiting
  • Ohio State University

    Columbus, Ohio, United States

    Recruiting
  • Prevention Science Institute

    Eugene, Oregon, United States

    Recruiting
  • Temple University

    Philadelphia, Pennsylvania, United States

    Recruiting
  • University of Pennsylvania

    Philadelphia, Pennsylvania, United States

    Recruiting
  • University of Pittsburgh School of Medicine

    Pittsburgh, Pennsylvania, United States

    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

MT1988 High DoseMT1988 Low DosePlacebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
3 Mar 2026
Primary completion
30 Sept 2027
Completion
31 Oct 2027
Last update posted
8 Jun 2026
Registered enrollment
150
Registry id
NCT07226895

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.