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Clinical trialNCT07265596RecruitingPhase 2Interventional

Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging)

SponsorMichael J. Fox Foundation for Parkinson's ResearchEnrollment100Prodromal Parkinsons Disease
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The study is a longitudinal, multi-center study to assess progression of \[18F\] AV-133 imaging in Prodromal PD participants. Participants will be followed for up to 24 months. Approximately 100 Prodromal participants will be recruited from up to 10 sites. Participants will be comprehensively assessed at baseline and follow up. Participants will undergo imaging assessments with \[18F\] AV-133 and clinical (motor, neuropsychiatric, cognitive and imaging and biomarker) assessments (conducted under the PPMI Clinical protocol).
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Toronto Western Hospital

    Toronto, Ontario, Canada

    Connie Marras
    Not, yet, recruiting
Germany
  • Philipps-University of Marburg

    Hessen, Germany

    Wolfgang Oertel
    Not, yet, recruiting
Israel
  • Tel Aviv Sourasky Medical Center

    Tel Aviv, Israel

    Roy Alcalay, MD
    Not, yet, recruiting
Netherlands
  • Radboud University

    Nijmegen, Gelderland, Netherlands

    Bastiaan Bloem, MD
    Not, yet, recruiting
United Kingdom
  • Queen Mary University of London

    London, Britain, United Kingdom

    Alastair Noyce, MDCristina Simonet, MD
    Recruiting
  • Newcastle University

    Newcastle upon Tyne, Tyne and Wear, United Kingdom

    David LedinghamNicola Pavese
    Recruiting
United States
  • Institute for Neurodegenerative Disorders

    New Haven, Connecticut, United States

    Neha Prakash, MBBS
    Recruiting
  • University of Pennsylvania

    Philadelphia, Pennsylvania, United States

    Nabila Dahodwala, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

[18F] AV-133 PET Imaging
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Oct 2023
Primary completion
31 Dec 2027
Completion
31 Dec 2027
Last update posted
5 Dec 2025
Registered enrollment
100
Registry id
NCT07265596
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.