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Clinical trialNCT07269041RecruitingPhase 1/PHASE2Interventional

Immune Tolerance Induction After Liver Transplantation

SponsorUniversity of California, Los AngelesEnrollment12ChimerismEnd Stage Liver DiseaseGraft SurvivalHematopoietic Stem CellImmune ToleranceImmune Tolerance/Drug Effects+3 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This clinical trial is being conducted to help liver transplant recipients safely discontinue toxic immunosuppressive drugs years after surgery. Lifelong use of these drugs is the current standard, but they come with life-threatening side effects. UCLA has pioneered this "Delayed Tolerance" approach, achieving success in numerous kidney recipients now living drug-free. The process uses a conditioning regimen followed by donor stem cell infusion to retrain the immune system to accept the liver as "self."
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Ucla Health 200 Medical Plaza

    Los Angeles, California, United States

    Ann Raldow, MDCaspian Oliai, MDCray V. Noah, MDJasleen Singh, MDJeffrey Veale, MDSamer Ebaid, MD, PhD, MS
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Donor Hematopoietic Stem and Progenitor Cell Infusion
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
20 Feb 2026
Primary completion
31 Jan 2029
Completion
31 Jan 2033
Last update posted
12 Mar 2026
Registered enrollment
12
Registry id
NCT07269041
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.