Clinical trialNCT07282340RecruitingPhase 2Interventional

Phentermine's Impact on Treatment in Teens

SponsorRussell McCulloh, MDEnrollment240Childhood Obesity

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

PhITT is a Phase IIb, multicenter, randomized, double-blind, placebo-controlled clinical trial evaluating the efficacy and safety of phentermine (16 mg daily) in adolescents aged 12 to \<18 years with obesity. Conducted across approximately 10 sites within the IDeA States Pediatric Clinical Trials Network (ISPCTN), the study aims to enroll up to 240 participants and then randomize up to 198 who meet eligibility criteria, randomized in a 2:1 ratio to phentermine or placebo over a 52-week treatment period, followed by a 2-week withdrawal assessment.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Russell McCulloh, MD
UNMC
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Nemours Children'S Hospital
Wilmington, Delaware, United States
Recruiting
Novak Center for Children'S Health
Louisville, Kentucky, United States
Recruiting
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States
Stephanie Waldrop, MD, MPH
Recruiting
Children'S Mercy Hospital
Kansas City, Missouri, United States
Helena Laroche, MD
Recruiting
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States
Kimberly Dovin, MD
Recruiting
University of New Mexico Health Sciences Center
Albuquerque, New Mexico, United States
Michele Hutchison, MD
Recruiting
the University of Oklahoma Health Sciences Children'S Hospital
Oklahoma City, Oklahoma, United States
Jeanie Tryggestad, MD
Recruiting
Prisma Health-Midlands Children'S Hospital
Columbia, South Carolina, United States
Lisa Knight, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PhenterminePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Jun 2026
Primary completion: 31 Jan 2028
Completion: 31 Jan 2028
Last update posted: 7 Oct 2026
Registered enrollment: 240
Registry id: NCT07282340

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.