Clinical trialNCT07283939RecruitingInterventional

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

SponsorAlliance for Clinical Trials in OncologyEnrollment420Ampulla of Vater CarcinomaAppendix CarcinomaCarcinoma of Unknown Primary With Gastrointestinal ProfileColon CarcinomaEsophageal CarcinomaGastric Carcinoma+4 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study seeks to learn whether using the PAGODA algorithm to guide chemotherapy dosing will lower the chance of unplanned delays during chemotherapy for cancer in the gastrointestinal system compared to usual care.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Gabriel A. Brooks, MD, MPH
Alliance for Clinical Trials in Oncology
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

363 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Guam

Fhp Health Center-Guam
Tamuning, Guam
Samir S. Ambrale
Recruiting

Puerto Rico

Cancer Center-Metro Medical Center Bayamon
Bayamón, Puerto Rico
Luis J. Santos Reyes
Recruiting
Puerto Rico Hematology Oncology Group
Bayamón, Puerto Rico
Luis J. Santos Reyes
Recruiting
Doctors Cancer Center
Manati, Puerto Rico
Luis J. Santos Reyes
Recruiting
Centro Comprensivo de Cancer de Upr
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting
Proncology
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting
San Juan City Hospital
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting
San Juan Community Oncology Group
San Juan, Puerto Rico
Luis J. Santos Reyes
Recruiting

United States

Fairbanks Memorial Hospital
Fairbanks, Alaska, United States
John M. Schallenkamp
Recruiting
Cancer Center at Saint Joseph'S
Phoenix, Arizona, United States
Shahzad Siddique
Recruiting
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States
Jay W. Carlson
Recruiting
Nea Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
Glenn W. Roma
Recruiting
Carti Cancer Center
Little Rock, Arkansas, United States
Jay W. Carlson
Recruiting
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center - Carmichael
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy San Juan Medical Center
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center - Elk Grove
Elk Grove, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center
Merced, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center - Rocklin
Rocklin, California, United States
Shahzad Siddique
Recruiting
Mercy Cancer Center - Sacramento
Sacramento, California, United States
Shahzad Siddique
Recruiting
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, United States
Shahzad Siddique
Recruiting
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, United States
Shahzad Siddique
Recruiting
Saint Joseph'S Medical Center
Stockton, California, United States
Shahzad Siddique
Recruiting
Woodland Memorial Hospital
Woodland, California, United States
Shahzad Siddique
Recruiting
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Saint Francis Cancer Center
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Commonspirit Cancer Center Mercy
Durango, Colorado, United States
Shahzad Siddique
Recruiting
Mercy Medical Center
Durango, Colorado, United States
Shahzad Siddique
Recruiting
Commonspirit Saint Anthony Hospital Cancer Center
Lakewood, Colorado, United States
Shahzad Siddique
Recruiting
Longmont United Hospital
Longmont, Colorado, United States
Shahzad Siddique
Recruiting
Saint Mary Corwin Medical Center
Pueblo, Colorado, United States
Shahzad Siddique
Recruiting
Saint Anthony North Hospital
Westminster, Colorado, United States
Shahzad Siddique
Recruiting
Beebe Medical Center
Lewes, Delaware, United States
Gregory A. Masters
Recruiting
Beebe South Coastal Health Campus
Millville, Delaware, United States
Gregory A. Masters
Recruiting
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Helen F Graham Cancer Center
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Medical Oncology Hematology Consultants Pa
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Beebe Health Campus
Rehoboth Beach, Delaware, United States
Gregory A. Masters
Recruiting
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, United States
Gregory A. Masters
Recruiting

323 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Fluorouracil →Leucovorin →Oxaliplatin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 13 Feb 2026
Primary completion: 1 May 2030
Completion: 2 May 2030
Last update posted: 5 Aug 2026
Registered enrollment: 420
Registry id: NCT07283939

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.