Clinical trialNCT07293247RecruitingPhase 2Interventional

A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment

SponsorAlliance for Clinical Trials in OncologyEnrollment164Lung Non-Small Cell Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial compares the effect of intensity-modulated post-operative radiation therapy (I²-PORT) followed by standard of care therapy (chemotherapy or immunotherapy) to standard of care therapy alone in treating patients with non-small cell lung cancer (NSCLC) who have remaining lymph node cancer after surgery. Radiation therapy uses high-energy X-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Intensity-modulated radiation therapy is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Adding I²-PORT radiation therapy to standard therapy may be more effective than standard therapy alone in reducing the risk of cancer returning in those who have undergone surgery for NSCLC.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David Kozono, MD
Alliance for Clinical Trials in Oncology
Study Chair
clinicaltrials.gov ↗
Jeremy Brownstein, MD
Alliance for Clinical Trials in Oncology
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

74 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Nea Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
Shelby Lane
Recruiting
Usc / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Joshua P. Schiff
Recruiting
Illinois Cancercare-Bloomington
Bloomington, Illinois, United States
Bryan A. Faller
Recruiting
Osf Saint Joseph Medical Center
Bloomington, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Canton
Canton, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Carthage
Carthage, Illinois, United States
Bryan A. Faller
Recruiting
Rush Md Anderson Cancer Center
Chicago, Illinois, United States
Gaurav Marwaha
Recruiting
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States
Bryan A. Faller
Recruiting
Decatur Memorial Hospital
Decatur, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Eureka
Eureka, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Galesburg
Galesburg, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Kewanee Clinic
Kewanee, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Macomb
Macomb, Illinois, United States
Bryan A. Faller
Recruiting
Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States
Bryan A. Faller
Recruiting
Hshs Saint Elizabeth'S Hospital
O'Fallon, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Ottawa Clinic
Ottawa, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Pekin
Pekin, Illinois, United States
Bryan A. Faller
Recruiting
Osf Saint Francis Radiation Oncology at Pekin
Pekin, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Peoria
Peoria, Illinois, United States
Bryan A. Faller
Recruiting
Osf Saint Francis Medical Center
Peoria, Illinois, United States
Bryan A. Faller
Recruiting
Osf Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Peru
Peru, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Princeton
Princeton, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare - Washington
Washington, Illinois, United States
Bryan A. Faller
Recruiting
Mainehealth Coastal Cancer Treatment Center
Bath, Maine, United States
Matthew D. Cheney
Recruiting
Mainehealth Cancer Care and Iv Therapy - Brunswick
Brunswick, Maine, United States
Matthew D. Cheney
Recruiting
Mainehealth Maine Medical Center - Portland
Portland, Maine, United States
Matthew D. Cheney
Recruiting
Mainehealth Cancer Care Center of York County
Sanford, Maine, United States
Matthew D. Cheney
Recruiting
Mainehealth Maine Medical Center- Scarborough
Scarborough, Maine, United States
Matthew D. Cheney
Recruiting
Mainehealth Cancer Care and Iv Therapy - South Portland
South Portland, Maine, United States
Matthew D. Cheney
Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, United States
Samir Narayan
Recruiting
Trinity Health Iha Medical Group Hematology Oncology - Brighton
Brighton, Michigan, United States
Samir Narayan
Recruiting
Trinity Health Medical Center - Brighton
Brighton, Michigan, United States
Samir Narayan
Recruiting
Trinity Health Iha Medical Group Hematology Oncology - Canton
Canton, Michigan, United States
Samir Narayan
Recruiting
Trinity Health Medical Center - Canton
Canton, Michigan, United States
Samir Narayan
Recruiting
Chelsea Hospital
Chelsea, Michigan, United States
Samir Narayan
Recruiting
Trinity Health Iha Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, United States
Samir Narayan
Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, United States
Samir Narayan
Recruiting
Trinity Health Iha Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, United States
Samir Narayan
Recruiting
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, United States
Daniel Almquist
Recruiting

34 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Chemotherapy →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Jul 2026
Primary completion: 31 Dec 2028
Completion: 1 Mar 2032
Last update posted: 5 Aug 2026
Registered enrollment: 164
Registry id: NCT07293247

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.