Clinical trialNCT07391774RecruitingPhase 3Interventional

Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

SponsorNational Cancer Institute (NCI)Enrollment1,978Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8Anatomic Stage IIIC Breast Cancer AJCC v8Estrogen Receptor-Positive Breast CarcinomaHER2-Negative Breast Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Nancy Chan
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

56 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Nea Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
Elizabeth John
Recruiting
Sutter Roseville Medical Center
Roseville, California, United States
Kristie A. Bobolis
Recruiting
Stamford Hospital/bennett Cancer Center
Stamford, Connecticut, United States
K.M. S. Lo
Recruiting
Medical Oncology Hematology Consultants Pa
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Kootenai Health - Coeur D'Alene
Coeur d'Alene, Idaho, United States
John M. Schallenkamp
Recruiting
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, United States
John M. Schallenkamp
Recruiting
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, United States
John M. Schallenkamp
Recruiting
Illinois Cancercare-Bloomington
Bloomington, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Canton
Canton, Illinois, United States
Bryan A. Faller
Recruiting
Sih Cancer Institute
Carterville, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Carthage
Carthage, Illinois, United States
Bryan A. Faller
Recruiting
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States
Bryan A. Faller
Recruiting
Decatur Memorial Hospital
Decatur, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Eureka
Eureka, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Galesburg
Galesburg, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Kewanee Clinic
Kewanee, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Macomb
Macomb, Illinois, United States
Bryan A. Faller
Recruiting
Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States
Bryan A. Faller
Recruiting
Hshs Saint Elizabeth'S Hospital
O'Fallon, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Ottawa Clinic
Ottawa, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Pekin
Pekin, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Peoria
Peoria, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Peru
Peru, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare-Princeton
Princeton, Illinois, United States
Bryan A. Faller
Recruiting
Southern Illinois University School of Medicine
Springfield, Illinois, United States
Bryan A. Faller
Recruiting
Springfield Clinic
Springfield, Illinois, United States
Bryan A. Faller
Recruiting
Springfield Memorial Hospital
Springfield, Illinois, United States
Bryan A. Faller
Recruiting
Illinois Cancercare - Washington
Washington, Illinois, United States
Bryan A. Faller
Recruiting
Mary Greeley Medical Center
Ames, Iowa, United States
Joseph J. Merchant
Recruiting
Mcfarland Clinic - Ames
Ames, Iowa, United States
Joseph J. Merchant
Recruiting
Ui Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, United States
Seema Harichand-Herdt
Recruiting
Saint Anthony Regional Hospital
Carroll, Iowa, United States
Seema Harichand-Herdt
Recruiting
Mercy Hospital
Cedar Rapids, Iowa, United States
Deborah W. Wilbur
Recruiting
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, United States
Deborah W. Wilbur
Recruiting
Ui Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, United States
Seema Harichand-Herdt
Recruiting
Broadlawns Medical Center
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Iowa Methodist Medical Center
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States
Richard L. Deming
Recruiting
Ui Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting
Ui Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, United States
Seema Harichand-Herdt
Recruiting

16 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Feb 2027
Primary completion: 31 Jul 2029
Completion: 31 Jul 2029
Last update posted: 10 Jul 2026
Registered enrollment: 1,978
Registry id: NCT07391774

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.