Clinical trialNCT07547540RecruitingPhase 1Interventional

A Study of LY3971297 in Participants With Heart Failure

SponsorEli Lilly and CompanyEnrollment90Heart FailureHeart Failure, DiastolicHeart Failure, Systolic

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The main purpose of this study is to assess how well LY3971297 is tolerated and what side effects may occur in participants with heart failure with preserved ejection fraction (HFpEF) and participants with heart failure with reduced ejection fraction (HFrEF). Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. For each participant, the study will last about 2 months and will include 1 inpatient visit lasting approximately 4 days and 5 outpatient visits.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Japan

Kobe University Hospital
Kobe, Japan
Hiromasa Otake
Not, yet, recruiting
Kyoto University Hospital
Kyoto, Japan
Koh Ono
Not, yet, recruiting
National Cerebral and Cardiovascular Center
Suita-shi, Japan
Takeshi Kitai
Not, yet, recruiting
National Hospital Organization Kasumigaura Medical Center
Tsuchiura-shi, Japan
Hidekazu Maruyama
Not, yet, recruiting

Moldova

Institut de Cardiologie
Chisina, Moldova
Valeriu Revenco
Not, yet, recruiting
Republican Clinical Hospital Arensia Exploratory Medicine
Chisinau, Moldova
Vasile Corcea
Recruiting

Netherlands

University Medical Center Groningen
Groningen, Netherlands
Daan Westenbrink
Not, yet, recruiting

Romania

Arensia Research Clinic at County Clinical Hospital, Cluj-Napoca
Cluj-Napoca, Romania
Mihaela Mocan
Not, yet, recruiting

United States

Henry Ford Health System
Detroit, Michigan, United States
David Lanfear →
Not, yet, recruiting
Washington University
St Louis, Missouri, United States
Gregory Ewald
Not, yet, recruiting
University of North Carolina, Division of Cardiology
Chapel Hill, North Carolina, United States
Kirkwood Adams
Not, yet, recruiting
Houston Methodist Hospital
Houston, Texas, United States
Mahwash Kassi
Not, yet, recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

LY3971297Placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 11 Aug 2026
Primary completion: 30 Nov 2027
Completion: 30 Nov 2027
Last update posted: 21 Aug 2026
Registered enrollment: 90
Registry id: NCT07547540

Cross-registrations

EU-CTR / CTIS (EudraCT)2026-525663-40-00

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.