Clinical trialNCT07556718RecruitingPhase 2Interventional

Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease

SponsorUniversity of MichiganEnrollment100Quiescent Crohn's Disease (CD)

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Many individuals with Crohn's disease continue to experience abdominal pain, bloating, or bowel habit changes even when their inflammation is controlled. Amitriptyline is a medication commonly used at low doses to treat irritable bowel syndrome (IBS) and abdominal pain. This study will assess whether amitriptyline is safe and reduces those ongoing GI symptoms in adults with Crohn's disease in remission.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Allen A. Lee, MD, MS
University of Michigan
Principal Investigator
clinicaltrials.gov ↗
Kinza Tareen, MD
University of Michigan
Principal Investigator
clinicaltrials.gov ↗
Prashant Singh, MD
University of Michigan
Principal Investigator
clinicaltrials.gov ↗
Shrinivas Bishu, MD
University of Michigan
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Michigan
Ann Arbor, Michigan, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Amitriptyline →Placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Jun 2026
Primary completion: 31 Dec 2029
Completion: 31 Dec 2029
Last update posted: 5 Jun 2026
Registered enrollment: 100
Registry id: NCT07556718

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.