Clinical trialNCT07563868RecruitingInterventional

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

SponsorMassachusetts General HospitalEnrollment20Treatment Resistant Depression (TRD)

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is being conducted at Massachusetts General Hospital (MGH) to explore whether adding psychedelic coaching can enhance the effects of ketamine or esketamine maintenance treatment in individuals with treatment-resistant depression (TRD). The investigators are currently enrolling participants who are receiving ongoing maintenance intravenous (IV) ketamine or intranasal esketamine (Spravato) treatment at the MGH Ketamine Clinic. Participation in the study will involve adding coaching sessions to your existing ketamine maintenance treatment.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David Mischoulon, MD/PhD
Massachusetts General Hospital and Harvard Medical School
Principal Investigator
clinicaltrials.gov ↗
Franklin King, MD
Massachusetts General Hospital and Harvard Medical School
Principal Investigator
clinicaltrials.gov ↗
Maren Nyer, PhD
Massachusetts General Hospital and Harvard Medical School
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Massachusetts General Hospital
Boston, Massachusetts, United States
David Mischoulon, MD, PhDFranklin King, MDMaren Nyer, PhD
Recruiting
Massachusetts General Hospital'S Depression and Clinical Research Program
Boston, Massachusetts, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 17 Apr 2026
Primary completion: 1 Apr 2027
Completion: 1 Apr 2028
Last update posted: 23 Jul 2026
Registered enrollment: 20
Registry id: NCT07563868

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.