Clinical trialNCT07566754Not, yet, recruitingPhase 2Interventional

MOTIF@FRESH: Modifying Organisms Transvaginally in Females @ FRESH

SponsorDouglas KwonEnrollment75Recurrent Bacterial Vaginosis (BV)

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The MOTIF@ FRESH trial will assess the safety and efficacy of "vaginal microbiome transplantation" (VMT). Healthy females will be enrolled to donate vaginal fluid which will be processed and transplanted in females with a history of recurrent bacterial vaginosis (BV), treated with antibiotics.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Caroline Mitchell, MD, MPH
Massachusetts General Hospital
Principal Investigator
clinicaltrials.gov ↗
Douglas S Kwon, MD, PhD
Ragon Institute of MGB, MIT, and Harvard
Principal Investigator
clinicaltrials.gov ↗
Krista Dong, MD
Ragon Institute of MGB, MIT, and Harvard
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

South Africa

Fresh Clinic
Durban, South Africa
Funidiswe Chonco, MDRosie Mngqbisa, MBChB, MPHSiphesihle R Ngcobo, MDThumbi Ndung'u, PhD

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Vaginal Microbiome TransplantationMetronidazole →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2026
Primary completion: 31 May 2027
Completion: 29 Feb 2028
Last update posted: 18 May 2026
Registered enrollment: 75
Registry id: NCT07566754

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.