Clinical trialNCT07646587RecruitingPhase 2Interventional

A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)

SponsorWindward BioEnrollment105COPD (Chronic Obstructive Pulmonary Disease)

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is trying to identify the right dose of a long-acting medicine called WIN378 for people with moderate - severe chronic obstructive pulmonary disease (COPD). WIN378 blocks the action of a protein called TSLP that causes inflammation in the lung and may contribute to COPD control and symptoms. The study will test how doses of WIN378 are handled by the body (pharmacokinetics) and assess the safety of the medicine and markers of COPD inflammation in exhaled breath and blood, lung function and COPD control (pharmacodynamics)

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Omar Khwaja, MD
Windward Bio
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Wb Contracted Clinical Research Site
Miami Lakes, Florida, United States
Recruiting
Wb Contracted Clinical Research Site
North Dartmouth, Massachusetts, United States
Recruiting
Wb Contracted Clinical Research Site
Charlotte, North Carolina, United States
Recruiting
Wb Contracted Clinical Research Site
McKinney, Texas, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboWIN378

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 2 Jun 2026
Primary completion: 17 Dec 2027
Completion: 7 Jan 2028
Last update posted: 22 Jun 2026
Registered enrollment: 105
Registry id: NCT07646587

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.