Clinical trialNCT07667803RecruitingPhase 3Interventional

A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM

SponsorAstraZenecaEnrollment4,500Weight Management

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This master study protocol, Study D7260C00015, covers 2 independent, pivotal studies, Study 1 and Study 2. Each study is a global, randomized, double-blind, parallel-group, multicenter, Phase III study to assess the efficacy and safety of elecoglipron compared with placebo adjunct to diet and exercise for weight management, in adults living with obesity or overweight with at least one weight-related comorbidity, and without T2DM (Study 1) or with T2DM (Study 2).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Dr. Ania Jastreboff, MD, PhD
Yale University
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Prof. Melanie Davies, MBChB
Diabetes Research Centre Leicester Diabetes Centre - Bloom University of Leicester
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

321 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Research Site
Buenos Aires, Argentina
Not, yet, recruiting
Research Site
Buenos Aires, Argentina
Not, yet, recruiting
Research Site
CABA, Argentina
Not, yet, recruiting
Research Site
CABA, Argentina
Not, yet, recruiting
Research Site
Caba, Argentina
Not, yet, recruiting
Research Site
Capital Federal, Argentina
Not, yet, recruiting
Research Site
Granadero Baigorria, Argentina
Not, yet, recruiting
Research Site
Lanus, Argentina
Not, yet, recruiting
Research Site
Rosario, Argentina
Not, yet, recruiting
Research Site
Rosario, Argentina
Not, yet, recruiting
Research Site
San Nicolás, Argentina
Not, yet, recruiting
Research Site
San Vicente, Argentina
Not, yet, recruiting

Australia

Research Site
Botany, Australia
Not, yet, recruiting
Research Site
Camberwell, Australia
Not, yet, recruiting
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Kotara, Australia
Not, yet, recruiting
Research Site
Maroubra, Australia
Not, yet, recruiting
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St Albans, Australia
Recruiting
Research Site
St Leonards, Australia
Not, yet, recruiting

Brazil

Research Site
Belém, Brazil
Not, yet, recruiting
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Brasília, Brazil
Not, yet, recruiting
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Campinas, Brazil
Not, yet, recruiting
Research Site
Campinas, Brazil
Not, yet, recruiting
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Curitiba, Brazil
Not, yet, recruiting
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Fortaleza, Brazil
Not, yet, recruiting
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Porto Alegre, Brazil
Not, yet, recruiting
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São José dos Campos, Brazil
Not, yet, recruiting
Research Site
São Paulo, Brazil
Not, yet, recruiting
Research Site
São Paulo, Brazil
Not, yet, recruiting
Research Site
São Paulo, Brazil
Not, yet, recruiting

Canada

Research Site
Calgary, Alberta, Canada
Not, yet, recruiting
Research Site
Calgary, Alberta, Canada
Not, yet, recruiting
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Vancouver, British Columbia, Canada
Not, yet, recruiting
Research Site
Victoria, British Columbia, Canada
Not, yet, recruiting
Research Site
Moncton, New Brunswick, Canada
Not, yet, recruiting
Research Site
Truro, Nova Scotia, Canada
Recruiting
Research Site
Brampton, Ontario, Canada
Not, yet, recruiting
Research Site
Hamilton, Ontario, Canada
Not, yet, recruiting
Research Site
Niagara Falls, Ontario, Canada
Not, yet, recruiting
Research Site
North York, Ontario, Canada
Not, yet, recruiting
Research Site
Sarnia, Ontario, Canada
Not, yet, recruiting

281 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

ElecoglipronPlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Jun 2026
Primary completion: 31 Jul 2028
Completion: 30 Jul 2029
Last update posted: 10 Jul 2026
Registered enrollment: 4,500
Registry id: NCT07667803

Cross-registrations

EU-CTR / CTIS (EudraCT)2025-524688-19

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.