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Clinical trialNCT07699107Not, yet, recruitingPhase 4Interventional

Adalimumab Dose Adjustment for Pediatric Uveitis Treatment Trial

SponsorNisha AcharyaEnrollment160Juvenile Idiopathic Arthritis Associated UveitisUveitis, Anterior
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this clinical trial is to learn whether children and young adults with well-controlled juvenile idiopathic arthritis (JIA)-associated uveitis or chronic anterior uveitis can safely take adalimumab (or biosimilar) injections less often while maintaining control of their disease. The main question it aims to answer is: can adalimumab/biosimilar injections be given less frequently without uveitis (eye inflammation) or arthritis (joint inflammation) returning? Researchers will compare adalimumab/biosimilar injection schedules of every 2 weeks, 4 weeks, 8 weeks, and 12 weeks to determine how injection frequency affects disease control. Participants will: * Take adalimumab/biosimilar injections every 2, 4, 8, or 12 weeks. * Attend study visits every 6 weeks over 24 weeks, with an additional follow-up visit at 48 weeks for checkups, tests, and questionnaires. * Keep a diary of how often they take adalimumab/biosimilar and other drugs they take for their uveitis/arthritis.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

18 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Italy
  • Meyer Children'S Hospital

    Florence, Italy

    Gabriele SimoniniIlaria Maccora
United Kingdom
  • University Hospitals Bristol and Weston

    Bristol, United Kingdom

    A V RamananCatherine Guly
  • University Hospitals of Leicester

    Leicester, United Kingdom

    Arani SridharBharat Kapoor
  • Alder Hey Children'S Hospital

    Liverpool, United Kingdom

    Gavin ClearyJose Gonzalez-Martin
  • Great Ormond Street Hospital

    London, United Kingdom

    Elena MoraitisHarry PetrushkinLola Solebo
  • Manchester University Nhs Foundation Trust

    Manchester, United Kingdom

    Jane Ashworth
  • Great North Children'S Hospital

    Newcastle upon Tyne, United Kingdom

    Sharmila Jandial
  • Norfolk and Norwich University Hospital

    Norwich, United Kingdom

    Kate ArmonNarman Puvanachandra
  • Sheffield Children'S Hospital

    Sheffield, United Kingdom

United States
  • University of California, Los Angeles

    Los Angeles, California, United States

    Edmund Tsui, MD
  • University of California, Davis

    Sacramento, California, United States

    Angel Herrera-Guerra, MD PhDParisa Emami-Naeini, MD MPH
  • University of California, San Francisco

    San Francisco, California, United States

    John Gonzales, MDNisha Acharya, MDThuy Doan, MD PhD
  • University of Miami

    Miami, Florida, United States

    Janet Davis, MDStephanie Llop, MD
  • Children'S Mercy Hospital

    Kansas City, Missouri, United States

    Ashley Cooper, MDErin Stahl, MD
  • Cincinnati Children'S Hospital

    Cincinnati, Ohio, United States

    Sheila Angeles-Han, MDVirginia Miraldi Utz, MD
  • Vanderbilt University Medical Center

    Nashville, Tennessee, United States

    Sapna Gangaputra, MD MPHThomas (Brent) Graham, MD MS
  • University of Texas, Austin

    Austin, Texas, United States

    Eric Crowell, MD MPH
  • University of Utah Health

    Salt Lake City, Utah, United States

    Marissa Larochelle, MD

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Sept 2026
Primary completion
31 May 2030
Completion
30 Nov 2030
Last update posted
13 Jul 2026
Registered enrollment
160
Registry id
NCT07699107

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.