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Clinical trialNCT07723482Not, yet, recruitingPhase 1/PHASE2Interventional

ML-016 in Advanced Cancer With Lung and/or Liver Involvement

SponsorBrYet US, Inc.Enrollment108Advanced Solid Tumor With Lung and/or Liver Involvement
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is an open-label, multi-center, phase 1/2 dose-escalation and dose expansion study evaluating the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of ML-016 in participants with advanced solid tumors with lung and/or liver involvement (primary or metastatic disease).
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Apostolia Tsimberidou, MD, PhD, FASCO, FAAAS

    BrYet US, Inc.

    Study Director
    clinicaltrials.gov ↗
  • Brenton Seidl, MBBS, BSc, FRACP

    Cancer Care Foundation Ltd, Sunshine Coast Haematology and Oncology Clinic

    Principal Investigator
    clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Southside Cancer Care Centre

    Miranda, New South Wales, Australia

    Paul de Souza
  • Illawarra Cancer Care Center, Wollongong Hospital

    Wollongong, New South Wales, Australia

    Udit Nindra
  • Sunshine Coast Haematology and Oncology Clinic

    Buderim, Queensland, Australia

    Brenton Seidl

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

ML-016
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Aug 2026
Primary completion
31 Aug 2027
Completion
31 Aug 2030
Last update posted
23 Jul 2026
Registered enrollment
108
Registry id
NCT07723482
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.