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Clinical trialNCT07756359Not, yet, recruitingPhase 4Interventional

Tirzepatide for Ileal Pouch-anal Anastomosis (IPAA) and Chronic High Bowel Frequency (I8F-NS-X008)

SponsorUniversity of North Carolina, Chapel HillEnrollment20Bowel Diseases, InflammatoryPouch, IlealPouches, Ileoanal
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this clinical trial is to learn if Tirzepatide (Zepbound) can decrease bowel frequency in patients that have an ileal-pouch anal anastomosis (IPAA or pouch) better than standard of care anti-diarrheal therapy. The main question it aims to answer is: Does Tirzepatide reduce bowel frequency better than standard of care anti-diarrheal therapy in patients that have a pouch Participants will: Visit the clinic 5 times, answer questions about symptoms daily, be assigned to take the study product as instructed and provide a stool sample 4 times.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Cedars Sinai Medical Center

    Beverly Hills, California, United States

    Andres Yarur, MD
  • Mayo Clinic

    Rochester, Minnesota, United States

    Laura Raffals, MD
  • Washington University School of Medicine

    St Louis, Missouri, United States

    Parakkal Deepak, MD
  • University of North Carolina

    Chapel Hill, North Carolina, United States

    Edward Barnes, MD, MPH
  • University of Utah

    Salt Lake City, Utah, United States

    Priscila Santiago, MD

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Diphenoxylate →Loperamide →Tirzepatide →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Sept 2026
Primary completion
30 Sept 2027
Completion
30 Sept 2027
Last update posted
10 Aug 2026
Registered enrollment
20
Registry id
NCT07756359
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.