Clinical trialNCT07769437RecruitingInterventional

Non-nutritive Sweeteners in Inflammatory Bowel Disease

SponsorUniversity Hospitals Cleveland Medical CenterEnrollment40Crohn Disease (CD)Inflamatory Bowel Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study will focus on the commonly used non-nutritive sweetener (NNS) sucralose (2 sachets/day resulting in daily dose: sucralose 2.5mg/kg) and its role in changing the gut microbiota in humans with IBD, compared to healthy non-IBD individuals. We will focus on studying IBD patients affected with CD as a proof of principle that could be tested later in other IBD subtype (ulcerative colitis or others specific surgical conditions).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Abigail Raffner, RD PhD
Case Western Reserve University
Principal Investigator
clinicaltrials.gov ↗
Fabio Cominelli, MD PhD
University Hospitals Cleveland Medical Center
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Uh Minoff Health Center
Chagrin Falls, Ohio, United States
Jeffry Katz, MD
Recruiting
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
Jeffry Katz, MDVu Nguyen, MD
Recruiting
Uh Westlake Health Center
Westlake, Ohio, United States
Vu Nguyen, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Feb 2025
Primary completion: 31 Dec 2026
Completion: 31 Dec 2026
Last update posted: 18 Aug 2026
Registered enrollment: 40
Registry id: NCT07769437

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.