Clinical trialNCT07877246RecruitingObservational

A Longitudinal Natural History Study of Immune Biomarkers in Neuropsychiatric Illness

SponsorNational Institute of Mental Health (NIMH)Enrollment5,000Neuroinflammatory DisordersNeuropsychiatric DisordersPost-Infectious Neuropsychiatric Disorders

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Background: Some brain or mental health conditions may be caused when a person s immune system attacks their own body. These are called immunologic neuropsychiatric disorders. In this natural history study, researchers want to see if they can find substances in the blood that can help them identify people with this kind of brain or mental illness. What they learn may help them find better ways to diagnose and treat these conditions in the future. Objective: To collect blood samples from people with a brain or mental illness that may be related to their immune system. Eligibility: People ages 1 month or older with a brain or mental illness that may be related to their immune system. Design: Participants will have 1 visit. This visit may be in person or by telehealth. They will answer a questionnaire about their health. They may have blood drawn for testing; this blood sample may also be taken at another medical facility and sent to the researchers. Researchers will look at the participant s medical records and images over time. Researchers will also collect leftover blood or other tissue samples that are taken in the course of a participant s routine health care. Participants may opt to have more visits. These visits will be every 3 to 12 months for up to 5 years. They will be asked about changes in their health since their last visit. They may opt to have blood drawn for research.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Christopher M Bartley, M.D.
National Institute of Mental Health (NIMH)
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Childrens Hospital, Los Angeles
Los Angeles, California, United States
Recruiting
National Institutes of Health Clinical Center
Bethesda, Maryland, United States
Recruiting
Brigham and Women'S Hospital
Boston, Massachusetts, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 19 Oct 2026
Primary completion: 17 Sept 2036
Completion: 30 Sept 2036
Last update posted: 22 Oct 2026
Registered enrollment: 5,000
Registry id: NCT07877246

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.