Efficacy and Safety Study of Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure
Summary
The lay summary the sponsor registered on ClinicalTrials.gov.
Investigators
The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.
- A. G. Kfoury, MD
Intermountain Health Care, Inc.
Principal Investigator - Andrew Kao, MD
Mid America Heart Institute, Saint Luke's Hospital
Principal Investigator - Barry Greenberg, MD
University of California at San Diego Medical Center
Principal InvestigatorKOL profile → - Barry London, MD
University of Pittsburgh Medical Center
Principal Investigator - Brian Jaski, MD
San Diego Cardiac Center
Principal Investigator - Daniel Pauly, MD
Shands Hospital, University of Florida at Gainesville
Principal Investigator - Dinesh K. Gupta, MD
Tennessee Center for Clinical Trials, Harton Regional Medical Center
Principal Investigator - Donna Mancini, MD
Columbia University Hospital
Principal Investigator - Douglas W. Losordo, MD
Northwestern University
Principal Investigator - Eric J. Eichhorn, MD, FACC
Cardiopulmonary Research Science and Technology Institutte, Medical City Dallas Hospital
Principal Investigator - Guillermo Torre, MD
The Methodist Hospital Research Institute
Principal Investigator - Jill Kalman, MD
Icahn School of Medicine at Mount Sinai
Principal Investigator - Joaquin E. Cigarroa, MD
Oregon Health and Science University
Principal Investigator - Marc Klapholz, MD
University of Medicine and Dentistry of New Jersey
Principal Investigator - Mariell Jessup, MD
University of Pennsylvania
Study Chair - Mark Dunlap, MD
MetroHealth Medical Center
Principal Investigator - Maryl R. Johnson, MD
University of Wisconsin, Madison
Principal Investigator - Paul J. Hauptman, MD
St. Louis University Hospital
Principal Investigator - Randall Starling, MD
The Cleveland Clinic
Principal Investigator - Stephanie H. Dunlap, DO
University of Cincinnati
Principal Investigator - Stephen Archer, MD
University of Chicago
Principal Investigator - Vinay Thohan, MD
Wake Forest University
Principal Investigator
A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.
Sites
22 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.
- San Diego Cardiac Center
San Diego, California, United States
- University of California at San Diego Medical Center
San Diego, California, United States
- Shands Hospital at University of Florida
Gainesville, Florida, United States
- Northwestern University
Chicago, Illinois, United States
- University of Chicago Medical Center
Chicago, Illinois, United States
- Mid America Heart Institute, Saint Luke'S Hospital
Kansas City, Missouri, United States
- St. Louis University Hospital
St Louis, Missouri, United States
- University of Medicine and Dentistry of New Jersey
Newark, New Jersey, United States
- Columbia University Hospital
New York, New York, United States
- Mount Sinai Medical Center
New York, New York, United States
- Wake Forest University
Winston-Salem, North Carolina, United States
- University of Cincinnati
Cincinnati, Ohio, United States
- Cleveland Clinic Foundation
Cleveland, Ohio, United States
- Metrohealth Medical Center
Cleveland, Ohio, United States
- Oregon Health and Science University
Portland, Oregon, United States
- Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
- University of Pittsburgh Medical Center, Presbyterian-Shadyside Hospital
Pittsburgh, Pennsylvania, United States
- Tennessee Center for Clinical Trials & Harton Regional Medical Center
Tullahoma, Tennessee, United States
- Cardiopulmonary Research Science and Technology Institute, Medical City Dallas Hospital
Dallas, Texas, United States
- Methodist Hospital
Houston, Texas, United States
- Intermountain Medical Center
Murray, Utah, United States
- University of Wisconsin
Madison, Wisconsin, United States
Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.
Drugs studied
No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →
Registration & key dates
Registry attributes as recorded on the ClinicalTrials.gov study record.
- Start
- 31 Mar 2007
- Primary completion
- 31 Aug 2010
- Completion
- 31 Aug 2012
- Last update posted
- 20 Aug 2014
- Registered enrollment
- 51
- Registry id
- NCT00454818
Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.