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Clinical trialNCT00545974CompletedPhase 4Interventional

Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia

SponsorUniversity of California, San FranciscoEnrollment81Frontal Lobe DementiaFrontotemporal Lobe DementiaSemantic Dementia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary objective of the study is to determine whether memantine is effective in slowing the rate of behavioral decline in frontotemporal dementia. The secondary objective of the study is to assess the safety and tolerability of long-term treatment with memantine in patients with frontotemporal dementia (FTD) or semantic dementia (SD). To determine whether memantine is effective in slowing the rate of cognitive decline in frontotemporal dementia. To evaluate whether memantine delays or decreases the emergence of parkinsonism in frontotemporal dementia. The tertiary objective of the study is to determine whether treatment with memantine affects changes in weight
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of California, Los Angeles

    Los Angeles, California, United States

  • University California, San Francisco

    San Francisco, California, United States

  • Mayo Clinic - Jacksonville

    Jacksonville, Florida, United States

  • Northwestern University

    Chicago, Illinois, United States

  • Johns Hopkins Hospital

    Baltimore, Maryland, United States

  • Mayo Clinic - Rochester

    Rochester, Minnesota, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, United States

  • University Hospitals of Cleveland / Case Medical Center

    Cleveland, Ohio, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Placebo pillMemantine
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Oct 2007
Primary completion
31 Dec 2012
Completion
31 Dec 2012
Last update posted
17 Nov 2020
Registered enrollment
81
Registry id
NCT00545974
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.