Clinical trialNCT00591058UnknownPhase 1Interventional

Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Glioma

SponsorTransMolecularEnrollment36AstrocytomaGBMGlioblastoma MultiformeMalignant GliomaOligodendroglioma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate the safety and biologically active dose of TM-601 in adult patients with recurrent malignant glioma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Burt Nabors, MD
University of Alabama at Birmingham
Principal Investigator
clinicaltrials.gov ↗
Gerry Linette, MD
Washington University at St. Louis
Principal Investigator
clinicaltrials.gov ↗
Glenn Lesser, MD
Wake Forest University
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Jeremy Rudnick, MD
Cedars-Sinai Medical Center
Principal Investigator
clinicaltrials.gov ↗
Maceij Mrugala, MD
University of Washington at Seattle
Principal Investigator
clinicaltrials.gov ↗
Sean Grimm, MD
Northwestern University
Principal Investigator
clinicaltrials.gov ↗
Steven Rosenfeld, MD, PhD
Columbia University
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama
Birmingham, Alabama, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
Northwestern University
Chicago, Illinois, United States
Washington University
St Louis, Missouri, United States
Columbia University
New York, New York, United States
Wake Forest University
Winston-Salem, North Carolina, United States
University of Washington
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

TM-601

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Feb 2008
Primary completion: 28 Feb 2010
Completion: 28 Feb 2010
Last update posted: 17 Jul 2009
Registered enrollment: 36
Registry id: NCT00591058

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.