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Clinical trialNCT00650091CompletedPhase 3Interventional

Evaluating the Effectiveness of Prednisone, Azathioprine, and N-acetylcysteine in Patients With IPF

SponsorDuke UniversityEnrollment264Pulmonary Fibrosis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Idiopathic pulmonary fibrosis (IPF) is a long-term lung disease that affects an individual's ability to breathe. In this randomized, double-blind, placebo-controlled trial, we assigned patients with idiopathic pulmonary fibrosis who had mild-to-moderate lung-function impairment to one of three groups - receiving a combination of prednisone, azathioprine, and NAC (combination therapy), NAC alone, or placebo - in a 1:1:1 ratio.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

26 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama - Birmingham

    Birmingham, Alabama, United States

  • University of California - Los Angeles

    Los Angeles, California, United States

  • University of California - San Francisco

    San Francisco, California, United States

  • National Jewish Medical and Research Center

    Denver, Colorado, United States

  • Yale University School of Medicine

    New Haven, Connecticut, United States

  • University of Miami Miller School of Medicine

    Miami, Florida, United States

  • University of Chicago

    Chicago, Illinois, United States

  • University of Louisville

    Louisville, Kentucky, United States

  • Tulane University

    New Orleans, Louisiana, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, United States

  • Brigham and Women'S Hospital

    Boston, Massachusetts, United States

  • University of Michigan

    Ann Arbor, Michigan, United States

  • Mayo Clinic

    Rochester, Minnesota, United States

  • St. Luke'S Hospital

    Chesterfield, Missouri, United States

  • Mount Sinai Hospital

    New York, New York, United States

  • Weill Medical College of Cornell University

    New York, New York, United States

  • Highland Hospital - University of Rochester Medical Center

    Rochester, New York, United States

  • Duke Universtiy

    Durham, North Carolina, United States

  • Cleveland Clinic

    Cleveland, Ohio, United States

  • Temple University

    Philadelphia, Pennsylvania, United States

  • University of Pennsylvania Health System

    Philadelphia, Pennsylvania, United States

  • Medical University of South Carolina

    Charleston, South Carolina, United States

  • Vanderbilt University

    Nashville, Tennessee, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, United States

  • University of Utah Health Research Center

    Salt Lake City, Utah, United States

  • University of Washington

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Oct 2009
Primary completion
31 Oct 2013
Completion
31 Jan 2014
Last update posted
2 Jun 2015
Registered enrollment
264
Registry id
NCT00650091

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.