Clinical trialNCT00851786CompletedPhase 2Interventional

Live Zoster Vaccine in HIV-Infected Adults on Antiretroviral Therapy

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment395HIV InfectionsHerpes Zoster

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Herpes zoster, or shingles, is the result of a viral infection that causes a painful skin rash, usually in older people or people with suppressed immune systems like those infected with HIV. The ZOSTAVAX vaccine has been shown to reduce the number of infections and symptoms of herpes zoster infection in people over the age of 60. The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of two doses of ZOSTAVAX in HIV-1-infected adults with conserved immune function (Cd4+ T cell counts \>=200 cells/uL) virologically suppressed on potent combination antiretroviral therapy (ART).

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Constance A. Benson, MD
University of California, San Diego
Study Chair
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Jeffrey L. Lennox, MD
Emory University
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

43 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alabama Therapeutics Crs
Birmingham, Alabama, United States
Ucla Care Center Crs
Los Angeles, California, United States
University of Southern California Crs
Los Angeles, California, United States
Stanford Crs
Palo Alto, California, United States
Ucsd, Avrc Crs
San Diego, California, United States
Ucsf Aids Crs
San Francisco, California, United States
Harbor-Ucla Med. Ctr. Crs
Torrance, California, United States
University of Colorado Hospital Crs
Aurora, Colorado, United States
Denver Public Health Crs
Denver, Colorado, United States
Georgetown University Crs (gu Crs)
Washington D.C., District of Columbia, United States
Univ. of Miami Aids Crs
Miami, Florida, United States
the Ponce de Leon Center Crs
Atlanta, Georgia, United States
Northwestern University Crs
Chicago, Illinois, United States
Rush Univ. Med. Ctr. Actg Crs
Chicago, Illinois, United States
Ihv Baltimore Treatment Crs
Baltimore, Maryland, United States
Johns Hopkins Adult Aids Crs
Baltimore, Maryland, United States
Beth Israel Deaconess Med. Ctr., Actg Crs
Boston, Massachusetts, United States
Bmc Actg Crs
Boston, Massachusetts, United States
Brigham and Women'S Hosp. Actg Crs
Boston, Massachusetts, United States
Massachusetts General Hospital Actg Crs
Boston, Massachusetts, United States
Henry Ford Hosp. Crs
Detroit, Michigan, United States
Washington U Crs
St Louis, Missouri, United States
Cooper Univ. Hosp. Crs
Camden, New Jersey, United States
New Jersey Medical School- Adult Clinical Research Ctr. Crs
Newark, New Jersey, United States
Cornell Crs
New York, New York, United States
Hiv Prevention & Treatment Crs
New York, New York, United States
Ny Univ. Hiv/aids Crs
New York, New York, United States
Univ. of Rochester Actg Crs
Rochester, New York, United States
Bronx-Lebanon Hosp. Ctr. Crs
The Bronx, New York, United States
Chapel Hill Crs
Chapel Hill, North Carolina, United States
Duke Univ. Med. Ctr. Adult Crs
Durham, North Carolina, United States
Greensboro Crs
Greensboro, North Carolina, United States
Univ. of Cincinnati Crs
Cincinnati, Ohio, United States
Case Crs
Cleveland, Ohio, United States
Metrohealth Crs
Cleveland, Ohio, United States
the Ohio State University Medical Center
Columbus, Ohio, United States
the Research & Education Group-Portland Crs
Portland, Oregon, United States
Hosp. of the Univ. of Pennsylvania Crs
Philadelphia, Pennsylvania, United States
Thomas Jefferson Univ. Med. Ctr. Crs
Philadelphia, Pennsylvania, United States
Pitt Crs
Pittsburgh, Pennsylvania, United States

3 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboZOSTAVAX

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Apr 2009
Primary completion: 22 Sept 2011
Completion: 3 Jan 2012
Last update posted: 4 Nov 2021
Registered enrollment: 395
Registry id: NCT00851786

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.