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Clinical trialNCT05007821CompletedPhase 2Interventional

Linezolid Dosing Strategies in Drug-Resistant TB

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment138TuberculosisTuberculosis, Multidrug-ResistantTuberculosis, Pulmonary
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of the study was to evaluate the efficacy (how well the medicines work) and tolerability (whether participants stop treatment because of side effects from a drug) of an anti-TB treatment regimen that compared two doses of linezolid (LZD), combined with bedaquiline (BDQ), delamanid (DLM), and clofazimine (CFZ). This study also measured the level of LZD and BDQ in the participants' blood.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Botswana
  • Gaborone Crs (site Id: 12701)

    Gaborone, South-East District, Botswana

Brazil
  • Instituto de Pesquisa Clinica Evandro Chagas (ipec) Crs (site Id: 12101)

    Rio de Janeiro, Brazil

Haiti
  • Gheskio Institute of Infectious Diseases and Reproductive Health (gheskio - Imis) Crs (site Id: 31730)

    Port-au-Prince, Haiti

  • Les Centres Gheskio Clinical Research Site (gheskio-Inlr) Crs (site Id: 30022)

    Port-au-Prince, Haiti

Peru
  • Barranco Crs (site Id: 11301)

    Lima, Peru

Philippines
  • de la Salle Health Science Institute Angelo King Medical Research Center (dlshsi-Akmrc) (site Id: 31981)

    Cavite, Philippines

South Africa
  • Wits Helen Joseph Hospital Crs (wits Hjh Crs) (site Id: 11101)

    Johannesburg, Gauteng, South Africa

  • Durban International Crs (site Id: 11201)

    Durban, KwaZulu-Natal, South Africa

  • Rustenburg Crs (site Id: 31684)

    Rustenburg, North West, South Africa

  • South African Tuberculosis Vaccine Initiative (satvi) Crs (site Id: 31793)

    Cape Town, Western Cape, South Africa

  • University of Cape Town Lung Institute (uctli) Crs (site Id: 31792)

    Cape Town, Western Cape, South Africa

Thailand
  • Thai Red Cross Aids Research Centre (trc-Arc) Crs (site Id: 31802)

    Pathum Wan, Bangkok, Thailand

  • Chiang Mai University Hiv Treatment (cmu Hiv Treatment) Crs (site Id: 31784)

    Chiang Mai, Thailand

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bedaquiline →ClofazimineDelamanidLinezolid →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
27 Sept 2022
Primary completion
14 Mar 2025
Completion
13 Jan 2026
Last update posted
1 May 2026
Registered enrollment
138
Registry id
NCT05007821
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.