Clinical trialNCT01302834CompletedPhase 3Interventional

Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer

SponsorRadiation Therapy Oncology GroupEnrollment987Head and Neck CancerPrecancerous Condition

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether radiation therapy is more effective with cisplatin or cetuximab in treating oropharyngeal cancer. PURPOSE: This phase III trial is studying radiation therapy with cisplatin or cetuximab to see how well it works in treating patients with oropharyngeal cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Andy M. Trotti, MD
H. Lee Moffitt Cancer Center and Research Institute
Principal Investigator
clinicaltrials.gov ↗
Maura Gillison, MD, PhD
Ohio State University
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

185 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Cancercare Manitoba
Winnipeg, Manitoba, Canada
Mcgill Cancer Centre at Mcgill University
Montreal, Quebec, Canada

United States

Providence Cancer Center
Anchorage, Alaska, United States
Auburn Radiation Oncology
Auburn, California, United States
Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center
Burbank, California, United States
Radiation Oncology Centers - Cameron Park
Cameron Park, California, United States
Mercy Cancer Center at Mercy San Juan Medical Center
Carmichael, California, United States
Enloe Cancer Center at Enloe Medical Center
Chico, California, United States
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Rebecca and John Moores Ucsd Cancer Center
La Jolla, California, United States
Kaiser Permanente - Division of Research - Oakland
Oakland, California, United States
Rohnert Park Cancer Center
Rohnert Park, California, United States
Radiation Oncology Center - Roseville
Roseville, California, United States
Mercy General Hospital
Sacramento, California, United States
Radiological Associates of Sacramento Medical Group, Incorporated
Sacramento, California, United States
Ucsf Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States
Facility name not stated
Santa Clara, California, United States
Kaiser Permanente Medical Center - South San Francisco
South San Francisco, California, United States
Solano Radiation Oncology Center
Vacaville, California, United States
Rocky Mountain Cancer Centers - Aurora
Aurora, Colorado, United States
Boulder Community Hospital
Boulder, Colorado, United States
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, United States
Porter Adventist Hospital
Denver, Colorado, United States
Swedish Medical Center
Englewood, Colorado, United States
Mckee Medical Center
Loveland, Colorado, United States
North Suburban Medical Center
Thornton, Colorado, United States
George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
New Britain, Connecticut, United States
Ccop - Christiana Care Health Services
Newark, Delaware, United States
North Broward Medical Center
Dearfield Beach, Florida, United States
Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, United States
Integrated Community Oncology Network at Southside Cancer Center
Jacksonville, Florida, United States
Integrated Community Oncology Network
Jacksonville Beach, Florida, United States
Baptist Medical Center South
Jascksonville, Florida, United States
University of Miami Sylvester Comprehensive Cancer Center - Miami
Miami, Florida, United States
Integrated Community Oncology Network - Orange Park
Orange Park, Florida, United States
Florida Hospital Cancer Institute at Florida Hospital Orlando
Orlando, Florida, United States
M.D. Anderson Cancer Center at Orlando
Orlando, Florida, United States
Florida Cancer Center - Palatka
Palatka, Florida, United States
Sacred Heart Cancer Center at Sacred Heart Hospital
Pensacola, Florida, United States
Flagler Cancer Center
Saint Augustine, Florida, United States

145 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CetuximabCisplatin

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jun 2011
Primary completion: 12 Jul 2018
Completion: 4 Sept 2025
Last update posted: 20 Jul 2026
Registered enrollment: 987
Registry id: NCT01302834

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.