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Clinical trialNCT01466088CompletedPhase 2Interventional

Efficacy, Safety, & Tolerability of AZD3480 Patients With Mild to Moderate Dementia of the Alzheimer's Type (AD)

SponsorTargacept Inc.Enrollment386Alzheimer's Disease
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Alzheimer's disease is the most common form of dementia and is the fourth leading cause of death among people 65 years of age and older. The global prevalence of the disease will increase significantly as the population ages, unless preventative treatments can be identified and marketed. The present study seeks to evaluate AZD3480 (TC-1734) compared to an approved medication (donepezil) shown to improve cognition and function in patients with Alzheimer's disease.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

33 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Czechia
  • Policlinic

    Choceň, Czechia

  • Brain-Soultherapy S.R.O.

    Kladno, Czechia

  • Bialbi.S.R.O. Psychiatrické Oddělení

    Litoměřice, Czechia

  • Psychiatricka Ambulance

    Olomouc, Czechia

  • Vojenska Nemocnice Psychiatricke Oddeleni

    Olomouc, Czechia

  • Clintrial

    Prague, Czechia

  • Pragtis S.R.O.

    Prague, Czechia

  • Psychosocialni Centrum

    Přerov, Czechia

Romania
  • Crucea Alba - Dr. Oros Si Asociatii - Societate Civila Medicala

    Oradea, Romania

  • Spitalul Clinic Judetean de Urgenta Sibiu

    Sibiu, Romania

  • Spitalul de Psihiatrie Sibiu

    Sibiu, Romania

  • Spitalul Clinic Judetean de Urgenta, Clinica Neurologie 2

    Timișoara, Romania

  • Spitalul Clinic Judetean de Urgenta, Clinica Psihiatrie

    Timișoara, Romania

Slovakia
  • Neurologicka Ambulancia, S.R.O.

    Banská Bystrica, Slovakia

  • Univerzitna Nemocnica Bratislava, Geronto-Psychiatrické Oddelenie

    Bratislava, Slovakia

  • Konzilium S.R.O.

    Dubnica nad Váhom, Slovakia

  • Neurologická Ambulancia

    Krompachy, Slovakia

Ukraine
  • Dnipropetrovsk Regional Clinical Hospital

    Dnipropetrovsk, Ukraine

  • Donetsk National Medical University of M. Gorky

    Donetsk, Ukraine

  • Donetsk Regional Clinical Psychiatric Hospital

    Donetsk, Ukraine

  • Crimean Republican Institution Psychoneurological Dispensary

    Kerch, Ukraine

  • Central Clinical Hospital Ukrzaliznytsi

    Kharkiv, Ukraine

  • Department of Age Physiology and Pathology of Nervous System; Institute of Gerontology Nams

    Kyiv, Ukraine

  • Lugansk Regional Clinical Psychoneurological Hospital

    Luhansk, Ukraine

  • Lviv National Medical University Named After Galytskyy

    Lviv, Ukraine

  • Lviv Regional Clinical Psychiatric Hospital

    Lviv, Ukraine

  • Odessa Regional Psychoneurology Dispensary

    Odesa, Ukraine

  • Odessa Regional Psychiatric Hospital # 2

    Oleksandrivka, Ukraine

  • Ukrainian Medical Stomatological Academy

    Poltava, Ukraine

  • Department #3 of the Kherson Regional Psychiatric Hospital

    Stepanovka, Ukraine

United States
  • Banner Alzheimer Institute

    Phoenix, Arizona, United States

  • Meridien Research

    Brooksville, Florida, United States

  • Md Clinical

    Hallandale, Florida, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AZD3480Donepezil →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Oct 2011
Primary completion
31 May 2014
Completion
31 May 2014
Last update posted
3 Jun 2015
Registered enrollment
386
Registry id
NCT01466088
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.