Clinical trialNCT01466114UnknownPhase 2Interventional

Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition

SponsorUniversity of California, Los AngelesEnrollment64Primary-progressive Multiple SclerosisRelapsing-remitting Multiple SclerosisSecondary-progressive Multiple Sclerosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Approximately 50% of people diagnosed with Multiple Sclerosis (MS) will develop problems with cognition. Currently, there are no FDA-approved treatments targeting cognitive function in Multiple Sclerosis. This trial will ascertain whether treatment with an estrogen pill, used in combination with standard MS anti-inflammatory drugs, can improve cognitive testing as compared to treatment with a placebo pill in combination with standard anti-inflammatory drugs in women with MS.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Rhonda Voskuhl, M.D.
University of California, Los Angeles
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California Los Angeles
Los Angeles, California, United States
Barbara Giesser, MDCallene Momtazee, MD
Recruiting
the University of Colorado Denver
Aurora, Colorado, United States
Completed
the University of New Mexico
Albuquerque, New Mexico, United States
Completed
the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Completed

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Norethindrone →Estriol

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Oct 2011
Primary completion: 31 Dec 2021
Completion: 30 Apr 2022
Last update posted: 6 Nov 2019
Registered enrollment: 64
Registry id: NCT01466114

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.