Clinical trialNCT02008773CompletedPhase 2Interventional

A Double-Blind Trial of Adjunctive Valacyclovir to Improve Cognition in Early Phase Schizophrenia

SponsorIndiana UniversityEnrollment170Schizophrenia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary aim of the study is to determine the efficacy of adjunctive valacyclovir, in comparison to placebo, to improve visual (Brief Visuospatial Memory Test) and working (composite score of the Spatial Span and Letter Number Span tests) memory in individuals who are HSV-1 positive and early in the course of schizophrenia. We hypothesize that individuals who are HSV-1 positive, but not those who are HSV-1 negative, will demonstrate significant valacyclovir efficacy for visual and working memory.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Alan Breier, MD
Indiana University
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Brent Wurfel, MD, PhD
Laureate Institute for Brain Research
Principal Investigator
clinicaltrials.gov ↗
Deepak D'Souza, MD
Yale University
Principal Investigator
clinicaltrials.gov ↗
Diane Highum, MD
Clinical Innovations
Principal Investigator
clinicaltrials.gov ↗
Evagelos Coskinas, MD, PhD
Clinical Innovations
Principal Investigator
clinicaltrials.gov ↗
Faith Dickerson, PhD
Shepard Pratt Health System
Principal Investigator
clinicaltrials.gov ↗
Gerald Maguire, MD
University of California, Riverside
Principal Investigator
clinicaltrials.gov ↗
Keith Nuechterlein, PhD
University of California, Los Angeles
Principal Investigator
clinicaltrials.gov ↗
Rishi Kakar, MD
Innovative Clinical Research, Inc.
Principal Investigator
clinicaltrials.gov ↗
Robert Buchanan, MD
University of Maryland
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Robert Litman, MD
Centers for Behavioral Health, LLC
Principal Investigator
clinicaltrials.gov ↗
Sheldon Preskorn, MD
University of Kansas (KUMC)
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Stephen Marder, MD
University of California, Los Angeles
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

C.I. Trials, Inc.-Los Angeles County
Bellflower, California, United States
University of California, Los Angeles
Los Angeles, California, United States
University of California, Riverside at C.I. Trials, Inc.-Inland Empire
Riverside, California, United States
C.I. Trials, Inc.-Orange County
Santa Ana, California, United States
Yale University
New Haven, Connecticut, United States
Innovative Clinical Research, Inc.
Lauderhill, Florida, United States
Indiana University Psychotic Disorders Clinic
Indianapolis, Indiana, United States
Prevention and Recovery Center for Early Psychosis
Indianapolis, Indiana, United States
University of Kansas Medical Center-Witchita
Wichita, Kansas, United States
Maryland Psychiatric Research Center
Baltimore, Maryland, United States
Centers for Behavioral Health, Llc
Rockville, Maryland, United States
Sheppard Pratt Health System
Towson, Maryland, United States
Laureate Institute for Brain Research
Tulsa, Oklahoma, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Valacyclovir HCI 500 mg tabletsPlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 26 Mar 2014
Primary completion: 20 Jun 2017
Completion: 20 Jun 2017
Last update posted: 30 Jan 2019
Registered enrollment: 170
Registry id: NCT02008773

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.