Clinical trialNCT04418011CompletedInterventional

Neuromodulation of Social Cognitive Circuitry in People With Schizophrenia Spectrum Disorders

SponsorCentre for Addiction and Mental HealthEnrollment70Schizoaffective DisorderSchizophreniaSchizophreniform Disorders

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

In this study, the investigators will be examining the effects of repetitive transcranial magnetic stimulation (rTMS) and intermittent theta burst stimulation (iTBS) on social cognitive impairments in individuals with schizophrenia spectrum disorders. Participants will be chosen by chance to receive either active rTMS stimulation, active iTBS stimulation, sham rTMS, or sham iTBS. The investigators predict that active 10Hz and iTBS stimulation will improve social cognitive impairments compared to sham stimulation. We aim to identify which type of active stimulation is most effective at inducing changes social cognition brain circuitry and secondarily which type of active stimulation is best tolerated and most effective at inducing changes in social cognitive performance.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Anil Malhotra, MD
The Feinstein Institute for Medical Research, Zucker Hillside Hospital
Principal Investigator
clinicaltrials.gov ↗
Aristotle Voineskos, MD
Centre for Addiction and Mental Health
Principal Investigator
clinicaltrials.gov ↗
Robert Buchanan, MD
Maryland Psychiatric Research Centre, University of Maryland
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Centre for Addiction and Mental Health
Toronto, Ontario, Canada

United States

Maryland Psychiatric Research Centre
Catonsville, Maryland, United States
the Feinstein Institute for Medical Research
Manhasset, New York, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Nov 2020
Primary completion: 2 Feb 2023
Completion: 2 Feb 2023
Last update posted: 17 Oct 2023
Registered enrollment: 70
Registry id: NCT04418011

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.