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Clinical trialNCT02230306TerminatedPhase 2Interventional

Phase II Study of Cobimetinib in Combination With Vemurafenib in Active Melanoma Brain Metastases

SponsorMelissa Burgess, MDEnrollment5Active Melanoma Brain Metastases
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate the effectiveness of the combination of vemurafenib with cobimetinib in patients with active melanoma brain metastases.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Harriet Kluger

    New Haven, Connecticut, United States

  • Mohammed Milhem, Md

    Iowa City, Iowa, United States

  • Anna Pavlick, Md

    New York, New York, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, United States

  • Ravi Amaravadi, Md

    Philadelphia, Pennsylvania, United States

  • Upmc Hillman Cancer Center

    Pittsburgh, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cobimetinib →Vemurafenib →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
28 Feb 2015
Primary completion
31 Mar 2016
Completion
31 Mar 2016
Last update posted
12 Oct 2017
Registered enrollment
5
Registry id
NCT02230306
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.