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Clinical trialNCT02445222RecruitingPhase 3Interventional

CAR-T Long Term Follow Up (LTFU) Study

SponsorNovartis PharmaceuticalsEnrollment1,400Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Per Health Authorities guidelines for gene therapy medicinal products that utilize integrating vectors (e.g. lentiviral vectors), long term safety and efficacy follow up of treated patients is required. The purpose of this study is to monitor all patients exposed to CAR-T therapied for 15 years following their last CAR-T (e.g. CTL019) infusion to assess the risk of delayed adverse events (AEs), monitor for replication competent lentivirus (RCL) and assess long-term efficacy, including vector persistence.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

118 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Novartis Investigative Site

    Camperdown, New South Wales, Australia

    Recruiting
  • Novartis Investigative Site

    Melbourne, Victoria, Australia

    Recruiting
  • Novartis Investigative Site

    Melbourne, Victoria, Australia

    Recruiting
  • Novartis Investigative Site

    Parkville, Victoria, Australia

    Withdrawn
  • Novartis Investigative Site

    Murdoch, Western Australia, Australia

    Recruiting
  • Novartis Investigative Site

    Herston, Australia

    Recruiting
Austria
  • Novartis Investigative Site

    Linz, Austria

    Withdrawn
  • Novartis Investigative Site

    Salzburg, Austria

    Recruiting
  • Novartis Investigative Site

    Vienna, Austria

    Recruiting
  • Novartis Investigative Site

    Vienna, Austria

    Recruiting
Belgium
  • Novartis Investigative Site

    Ghent, Belgium

    Recruiting
Canada
  • Novartis Investigative Site

    Hamilton, Ontario, Canada

    Recruiting
  • Novartis Investigative Site

    Toronto, Ontario, Canada

    Recruiting
  • Novartis Investigative Site

    Montreal, Quebec, Canada

    Recruiting
  • Novartis Investigative Site

    Montreal, Quebec, Canada

    Recruiting
China
  • Novartis Investigative Site

    Beijing, China

    Recruiting
Denmark
  • Novartis Investigative Site

    Copenhagen, Denmark

    Recruiting
Finland
  • Novartis Investigative Site

    Helsinki, Finland

    Recruiting
France
  • Novartis Investigative Site

    Nantes, France

    Recruiting
  • Novartis Investigative Site

    Paris, France

    Recruiting
  • Novartis Investigative Site

    Paris, France

    Recruiting
  • Novartis Investigative Site

    Pierre-Bénite, France

    Recruiting
  • Novartis Investigative Site

    Villejuif, France

    Recruiting
Germany
  • Novartis Investigative Site

    Munich, Bavaria, Germany

    Recruiting
  • Novartis Investigative Site

    Regensburg, Bavaria, Germany

    Recruiting
  • Novartis Investigative Site

    Würzburg, Bavaria, Germany

    Recruiting
  • Novartis Investigative Site

    Frankfurt am Main, Hesse, Germany

    Recruiting
  • Novartis Investigative Site

    Cologne, North Rhine-Westphalia, Germany

    Recruiting
  • Novartis Investigative Site

    Leipzig, Saxony, Germany

    Recruiting
  • Novartis Investigative Site

    Berlin, Germany

    Recruiting
  • Novartis Investigative Site

    Hamburg, Germany

    Recruiting
  • Novartis Investigative Site

    Ulm, Germany

    Recruiting
Greece
  • Novartis Investigative Site

    Chaïdári, Greece

    Recruiting
Hong Kong
  • Novartis Investigative Site

    Hong Kong, Hong Kong

    Recruiting
Israel
  • Novartis Investigative Site

    Ramat Gan, Israel

    Recruiting
  • Novartis Investigative Site

    Tel Aviv, Israel

    Recruiting
Italy
  • Novartis Investigative Site

    Bologna, BO, Italy

    Recruiting
  • Novartis Investigative Site

    Monza, MB, Italy

    Recruiting
  • Novartis Investigative Site

    Milan, MI, Italy

    Recruiting
  • Novartis Investigative Site

    Milan, MI, Italy

    Recruiting
78 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
2 Nov 2015
Primary completion
22 Feb 2036
Completion
22 Feb 2036
Last update posted
28 Oct 2025
Registered enrollment
1,400
Registry id
NCT02445222

Cross-registrations

EU-CTR / CTIS (EudraCT)2014-001673-14
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.