Clinical trialNCT06876649RecruitingPhase 4Interventional

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

SponsorEli Lilly and CompanyEnrollment787Chronic Lymphocytic LeukemiaNon-Hodgkin Lymphoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The master protocol study J2N-MC-JZNY provides a framework to enable the evaluation of the long-term safety and efficacy of pirtobrutinib after completion of clinical studies evaluating pirtobrutinib. The clinical studies that will feed into this master protocol are referred to as originator studies. The master protocol will govern individual study-specific appendices (ISAs) that will represent participants from the individual, completed originator studies. These participants will have the opportunity to enter this study and continue to receive treatment or continue follow-up visits. Overall, the master protocol and the individual ISAs, when combined, define the investigations for this study.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

38 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Flinders Medical Centre
Adelaide, Australia
Hui-Peng Lee
Recruiting
Peter Maccallum Cancer Centre
Melbourne, Australia
John Seymour
Recruiting
Linear Clinical Research
Victoria, Australia
Chan Cheah
Recruiting

France

Chu de Nantes - Hotel Dieu
Nantes, France
Thomas Gastinne
Recruiting

Italy

Irccs-Aou Di Bologna-Policlinico S.Orsola-Malpighi
Bologna, Italy
Pier Luigi Zinzani
Recruiting
Ospedale San Raffaele
Milan, Italy
Paolo Ghia
Recruiting

Japan

Nagoya Medical Center
Aichi-Ken, Japan
Hirokazu Nagai
Recruiting
National Cancer Center Hospital
Cho-ku, Japan
Koji Izutsu
Recruiting
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan
Kaname Miyashita
Recruiting
Tokai University Hospital- Isehara Campus
Isehara, Japan
Yoshiaki Ogawa
Recruiting
Tohoku University Hospital
Miyagi-Ken, Japan
Noriko Fukuhara
Recruiting
Hokkaido University Hospital
Sapporo, Japan
Daigo Hashimoto
Recruiting

Poland

Pratia Mcm Krakow
Krakow, Poland
Wojciech Jurczak
Recruiting
Instytut Hermatologii I Transfuzjologii
Warsaw, Poland
Ewa Lech-Maranda
Recruiting

South Korea

Seoul National University Hospital
Seoul, South Korea
Ja Min Byun
Recruiting

United Kingdom

St James'S University Hospital
Leeds, United Kingdom
Talha Munir
Recruiting
Churchill Hospital
Oxford, United Kingdom
Toby Eyre
Not, yet, recruiting
Derriford Hospital
Plymouth, United Kingdom
David John Lewis
Recruiting

United States

Cancer Specialists, Llc
Jacksonville, Florida, United States
Ayed Ayed
Not, yet, recruiting
Sylvester Comprehensive Cancer Center
Miami, Florida, United States
Alvaro Alencar
Recruiting
Florida Cancer Specialists
Sarasota, Florida, United States
Manish Patel
Recruiting
the Emory Clinic
Atlanta, Georgia, United States
Jonathon Cohen
Not, yet, recruiting
Northwestern University
Chicago, Illinois, United States
Shuo Ma
Not, yet, recruiting
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Jennifer Brown
Recruiting
Mayo Clinic- Minnesota
Rochester, Minnesota, United States
Yucai Wang
Recruiting
University of Nebraska Medical Center
Omaha, Nebraska, United States
Matthew Lunning
Recruiting
Cayuga Cancer Center
Ithaca, New York, United States
Cynthia Davis
Recruiting
Northwell Health
Lake Success, New York, United States
Steven Allen
Recruiting
Memorial Sloan-Kettering Cancer Center (mskcc) - New York
New York, New York, United States
Prioty Islam
Recruiting
Memorial Sloan-Kettering Cancer Center (mskcc) - New York
New York, New York, United States
Prioty Islam
Not, yet, recruiting
Memorial Sloan-Kettering Cancer Center (mskcc) - New York
New York, New York, United States
Prioty Islam
Not, yet, recruiting
Duke University Medical Center
Durham, North Carolina, United States
Matthew McKinney
Recruiting
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Jennifer Woyach
Recruiting
University of Pennsylvania Hospital
Philadelphia, Pennsylvania, United States
Sunita Nasta
Recruiting
Tennessee Oncology
Nashville, Tennessee, United States
Michael Byrne
Recruiting
University of Texas Md Anderson Cancer Center
Houston, Texas, United States
Michael Wang
Recruiting
Swedish Cancer Institute
Seattle, Washington, United States
Swathi Namburi
Recruiting
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Nirav Shah
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Pirtobrutinib

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 20 May 2025
Primary completion: 31 May 2030
Completion: 31 Dec 2032
Last update posted: 2 Mar 2026
Registered enrollment: 787
Registry id: NCT06876649

Cross-registrations

EU-CTR / CTIS (EudraCT)2024-517760-29-00

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.