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Clinical trialNCT02950883CompletedPhase 2/PHASE3Interventional

Saline Hypertonic in Preschoolers + CT

SponsorUniversity of Washington, the Collaborative Health Studies Coordinating CenterEnrollment116Cystic Fibrosis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to assess whether inhalation of 7% hypertonic saline (HS) twice daily for 48 weeks reduces structural lung disease as assessed by computed tomography (CT) in comparison with inhalation of 0.9% isotonic saline (IS) in preschool children (ages 3 to 6) with cystic fibrosis.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

25 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Royal Women'S and Children Hospital

    Adelaide, Australia

  • Lady Cilento Children'S Hospital

    Brisbane, Australia

  • Royal Children'S Hospital

    Melbourne, Australia

  • John Hunter Children'S Hospital

    Newcastle, Australia

  • Children'S Hospital at Westmead

    Sydney, Australia

  • Sydney Children'S Hospital at Randwick

    Sydney, Australia

  • Perth Children'S Hospital

    West Perth, Australia

Belgium
  • Universitair Ziekenhuis Children'S Hospital

    Brussels, Belgium

  • Uz Leuven - Gasthuisberg Ziekenhuis

    Leuven, Belgium

Canada
  • British Columbia Children'S Hospital

    Vancouver, British Columbia, Canada

  • Hospital for Sick Kids

    Toronto, Ontario, Canada

Denmark
  • Copenhagen University Hospital Rigshospitalet

    Copenhagen, Denmark

France
  • Hospice Civils de Lyon

    Lyon, France

  • Hospital Robert Debre

    Paris, France

Italy
  • Bambini Gesu Children'S Hospital

    Roma, Italy

  • Ospedale Civile Maggiore

    Verona, Italy

Netherlands
  • Sophia Children'S Hospital at Erasmus Medical Centre

    Rotterdam, Netherlands

Spain
  • Hospital Universitari Vall D'Hebron

    Barcelona, Spain

United States
  • Children'S Hospital of Colorado

    Aurora, Colorado, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, United States

  • Oregon Health Sciences University

    Portland, Oregon, United States

  • Children'S Hospital of Pittsburgh of Upmc

    Pittsburgh, Pennsylvania, United States

  • Seattle Children'S Hospital

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Active Treatment Group 7% Hypertonic SalineControl Group 0.9% Isotonic Saline
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
24 Mar 2015
Primary completion
15 Dec 2020
Completion
25 Jun 2021
Last update posted
12 Mar 2024
Registered enrollment
116
Registry id
NCT02950883
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.