Clinical trialNCT03021928UnknownPhase 3Interventional

Optimal Delay Time to Initiate Anticoagulation After Ischemic Stroke in Atrial Fibrillation

SponsorUniversity of Texas at AustinEnrollment200Stroke

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Title: Optimal Delay Time to Initiate Anticoagulation after Ischemic Stroke in Atrial Fibrillation (START): a pragmatic, adaptive randomized clinical trial. Primary Objective: • To determine the optimal time to initiate anticoagulation with a Non-Vitamin K Oral Anticoagulant (NOAC) after ischemic stroke in patients with non-valvular atrial fibrillation. Secondary Objectives: * To compare the rates of primary adverse outcomes in a per protocol analysis * To compare 30 day clinical outcomes by the modified Rankin scale among the time-to-treatment groups * To compare 90 day clinical outcomes by the modified Rankin scale among the time-to-treatment groups * To explore the optimal timing in subgroups of age, sex, outcome category, and NOAC choice

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Patrick Lawrence, BS
University of Texas at Austin
Study Chair
clinicaltrials.gov ↗
Steven Warach, MD, PhD
University of Texas at Austin
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Truman J Milling, MD
University of Texas at Austin
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

15 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Dell Seton Medical Center at the University of Texas
Austin, Texas, United States
Seton Medical Center Austin
Austin, Texas, United States
St. David'S Medical Center
Austin, Texas, United States
Chi St. Joseph Health Regional Hospital
Bryan, Texas, United States
Baylor University Medical Center
Dallas, Texas, United States
Parkland Memorial Hospital
Dallas, Texas, United States
Texas Health Presbyterian Hospital
Dallas, Texas, United States
Ut Southwestern William P. Clements Hospital
Dallas, Texas, United States
Ut Southwestern Zale Lipshy University Hospital
Dallas, Texas, United States
Texas Tech University Health Science Center - El Paso University Medical Center
El Paso, Texas, United States
Texas Health Harris Methodist Hospital
Fort Worth, Texas, United States
the University of Texas Health Science Center at Houston
Houston, Texas, United States
Seton Medical Center Hays
Kyle, Texas, United States
Seton Medical Center Williamson
Round Rock, Texas, United States
the University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Jun 2017
Primary completion: 3 Aug 2023
Completion: 31 Dec 2023
Last update posted: 8 Aug 2023
Registered enrollment: 200
Registry id: NCT03021928

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.