Clinical trialNCT03149991CompletedPhase 4Interventional

A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)

SponsorMassachusetts General HospitalEnrollment51Depression

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multi-site, double-blind, placebo-controlled study of the acute efficacy of brexpiprazole or placebo in combination with intranasal ketamine added to ongoing, stable, and adequate antidepressant therapy (ADT) in the treatment of adults with Major Depressive Disorder with Treatment Resistant Depression.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Maurizio Fava, MD
Massachusetts General Hospital
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Collaborative Neuroscience Network, Llc.
Garden Grove, California, United States
Pacific Research Partners, Llc
Oakland, California, United States
Rush University Medical Center
Chicago, Illinois, United States
Massachusetts General Hospital, Depression Clinical and Research Program
Boston, Massachusetts, United States
Nathan Kline Institute for Psychiatric Research
Orangeburg, New York, United States
Montefiore Medical Center
The Bronx, New York, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Brexpiprazole →KetaminePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Sept 2017
Primary completion: 31 Mar 2019
Completion: 15 Jun 2019
Last update posted: 24 Jul 2020
Registered enrollment: 51
Registry id: NCT03149991

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.