Clinical trialNCT03497676CompletedPhase 1/PHASE2Interventional

More Options for Children and Adolescents (MOCHA): Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in HIV-Infected Children and Adolescents

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment168HIV Infections

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study was to determine the dosage for oral cabotegravir (CAB) and long-acting cabotegravir (CAB LA) and long-acting rilpiverine (RPV LA) and evaluate the safety, acceptability, tolerability, and pharmacokinetics (PK) of oral CAB, CAB LA, and RPV LA in virologically suppressed children and adolescents living with HIV.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Aditya H. Gaur, MD
St. Jude Children's Research Hospital
Study Chair
clinicaltrials.gov ↗
Carolyn Bolton Moore, MSc, MBBCh
Centre for Infectious Disease Research in Zambia/University of Alabama Birmingham
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

19 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Botswana

Gaborone Crs
Gaborone, South-East District, Botswana
Molepolole Crs, Site 12702
Molepolole, Botswana

South Africa

Famcru Crs
Tygerberg Hills, Western Cape, South Africa
Wits Rhi Shandukani Research Centre Crs
Johannesburg, South Africa
Soweto Crs, Site 8052
Soweto, South Africa
Umlazi Crs
Umlazi, South Africa

Thailand

Siriraj Hospital Mahidol University
Bangkok, Thailand
Chiang Mai University Hiv Treatment (cmu Hiv Treatment) Crs
Chiang Mai, Thailand
Chiangrai Prachanukroh Hospital Nichd Crs
Chiang Mai, Thailand

Uganda

Baylor-Uganda Crs
Kampala, Uganda
Mu-Jhu Care Limited Crs
Kampala, Uganda

United States

Usc la Nichd Crs
Los Angeles, California, United States
Univ. of Colorado Denver Nichd Crs
Aurora, Colorado, United States
Pediatric Perinatal Hiv Nichd Crs, Site 5127
Miami, Florida, United States
Emory University School of Medicine Nichd Crs
Atlanta, Georgia, United States
Lurie Children'S Hospital of Chicago (lch) Crs
Chicago, Illinois, United States
Johns Hopkins Univ. Baltimore Nichd Crs
Baltimore, Maryland, United States
St. Jude Children'S Research Hospital Crs
Memphis, Tennessee, United States
Baylor College of Medicine/ Texas Children'S Hospital Nichd Crs
Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Combination Antiretroviral TherapyLong-Acting Injectable CabotegravirLong-Acting Injectable RilpivirineCabotegravir →Rilpivirine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Apr 2019
Primary completion: 18 Feb 2023
Completion: 22 Apr 2025
Last update posted: 28 Jan 2026
Registered enrollment: 168
Registry id: NCT03497676

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.