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Clinical trialNCT04196413RecruitingPhase 1Interventional

GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG)

SponsorStanford UniversityEnrollment97Glioma of BrainstemGlioma of Spinal Cord
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary purpose of this study is to test whether CAR T cells targeting GD2 (GD2CART) can be successfully made and safely given to children and adults with H3K27M-mutant diffuse midline glioma (DMG). Eligible subjects may have DMG arising in the pons (called difuse intrinisic pontine glioma, DIPG), the spinal cord, or other areas of the brain such as a thalamus
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Lucile Packard Children'S Hospital (lpch)

    Stanford, California, United States

    Brian Scott, MDCatherine Aftandilian, MDChelsey Burke, MDClaire Johns, MDCrystal Mackall, MDCynthia Campen, MDGordon Li, MDJay Balagtas, MDJulie Ma, MDKara Davis, D.O.Katherine Ryan, MDKun-Wei Song, MDLaura Prolo, M.DLianna Marks, MDLindsey Rasmussen, MDLiora Schultz, MDMark Halverson, MDMichael Lim, MDMichelle Monje, MD, PHDNorman Lacayo, MDPaul Fisher, MDRaya Saab, MDRichard Sleightholm, MDSaurabh Dahiya, MDSneha Ramakrishna, MDSonia Partap, MDSusan Hiniker, MDTanja Gruber, MD, PhdTimothy Cornell, MDWen-Kai Weng, MD, PhdYong Kim, MDZachary Threlkeld, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cyclophosphamide →Fludarabine →GD2 CAR T cellsRituximab →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
4 Jun 2020
Primary completion
31 Jul 2028
Completion
31 Jul 2043
Last update posted
26 Jan 2026
Registered enrollment
97
Registry id
NCT04196413
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.