Clinical trialNCT04475432CompletedPhase 2/PHASE3Interventional

Safety and Efficacy of TP-03 for the Treatment of Demodex Blepharitis

SponsorTarsus Pharmaceuticals, Inc.Enrollment421Blepharitis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to compare the safety and efficacy of TP-03, 0.25%, an eyedrop, to its vehicle control for the treatment of blepharitis due to Demodex, a microscopic mite frequently found in human hair follicles. The hypothesis for the study is the proportion of participants cured at Day 43 with treatment by TP-03, 0.25%, is greater than the proportion cured by treatment with its vehicle.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

David Wirta, MD
Eye Research Foundation
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

15 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Cornea and Cataract Consultants of Arizona
Phoenix, Arizona, United States
Eye Research Foundation
Newport Beach, California, United States
Visionary Eye Institute
Newport Beach, California, United States
Vision Institute
Colorado Springs, Colorado, United States
Midwest Cornea Associates, Llc
Carmel, Indiana, United States
Washburn Research Llc
Indianapolis, Indiana, United States
the Eye Care Institute
Louisville, Kentucky, United States
Andover Eye Associates
Andover, Massachusetts, United States
Ophthalmology Associates
St Louis, Missouri, United States
Oculus Research, Inc at Eyecarecenter
Raleigh, North Carolina, United States
Vita Eye Clinic
Shelby, North Carolina, United States
Scott & Christie and Associates, Pc
Cranberry Township, Pennsylvania, United States
Total Eye Care, P.A.
Memphis, Tennessee, United States
Alpine Research Organization
Layton, Utah, United States
Piedmont Eye Center
Lynchburg, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

TP-03 VehicleTP-03, 0.25%

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 9 Sept 2020
Primary completion: 4 May 2021
Completion: 4 May 2021
Last update posted: 21 Dec 2023
Registered enrollment: 421
Registry id: NCT04475432

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.