Clinical trialNCT04858334RecruitingPhase 2Interventional

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

SponsorNational Cancer Institute (NCI)Enrollment152Pancreatic Acinar Cell CarcinomaPancreatic Adenosquamous CarcinomaPancreatic Squamous Cell CarcinomaResectable Pancreatic Acinar Cell CarcinomaResectable Pancreatic AdenocarcinomaResectable Pancreatic Adenosquamous Carcinoma+1 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation in BRCA1, BRCA2, or PALB2. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Kim A Reiss Binder
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

454 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Israel

Rambam Medical Center
Haifa, Israel
Suspended

Puerto Rico

Pan American Center for Oncology Trials Llc - Dorado
Dorado, Puerto Rico
Marcia R. Cruz-Correa
Recruiting
Pan American Center for Oncology Trials Llc
San Juan, Puerto Rico
Marcia R. Cruz-Correa
Recruiting

United States

Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Suspended
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Suspended
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Suspended
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Suspended
Anchorage Oncology Centre
Anchorage, Alaska, United States
Suspended
Anchorage Radiation Therapy Center
Anchorage, Alaska, United States
Suspended
Katmai Oncology Group
Anchorage, Alaska, United States
Suspended
Providence Alaska Medical Center
Anchorage, Alaska, United States
Suspended
Fairbanks Memorial Hospital
Fairbanks, Alaska, United States
Suspended
Kingman Regional Medical Center
Kingman, Arizona, United States
John A. Ellerton
Recruiting
Cancer Center at Saint Joseph'S
Phoenix, Arizona, United States
Active, not recruiting
Mercy Hospital Fort Smith
Fort Smith, Arkansas, United States
Suspended
Chi Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas, United States
Suspended
Nea Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
Stephen W. Behrman
Recruiting
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, United States
Active, not recruiting
Pcr Oncology
Arroyo Grande, California, United States
Suspended
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States
Ari D. Baron
Recruiting
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Suspended
Palo Alto Medical Foundation-Fremont
Fremont, California, United States
Ari D. Baron
Recruiting
Memorial Medical Center
Modesto, California, United States
Ari D. Baron
Recruiting
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View, California, United States
Suspended
Saint Joseph Hospital - Orange
Orange, California, United States
Timothy E. Byun
Recruiting
Sutter Roseville Medical Center
Roseville, California, United States
Ari D. Baron
Recruiting
Sutter Medical Center Sacramento
Sacramento, California, United States
Ari D. Baron
Recruiting
California Pacific Medical Center-Pacific Campus
San Francisco, California, United States
Ari D. Baron
Recruiting
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, United States
Active, not recruiting
Mills Health Center
San Mateo, California, United States
Ari D. Baron
Recruiting
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California, United States
Ari D. Baron
Recruiting
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, United States
Active, not recruiting
Providence Medical Foundation - Santa Rosa
Santa Rosa, California, United States
Alison K. Conlin
Recruiting
Providence Santa Rosa Memorial Hospital
Santa Rosa, California, United States
Suspended
Sutter Pacific Medical Foundation
Santa Rosa, California, United States
Ari D. Baron
Recruiting
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California, United States
Ari D. Baron
Recruiting
Northbay Cancer Center
Vacaville, California, United States
Brian G. Vikstrom
Recruiting
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, United States
Active, not recruiting
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, United States
Active, not recruiting
Adventhealth Porter
Denver, Colorado, United States
Suspended

414 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Olaparib →Placebo Administration

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Jun 2021
Primary completion: 31 Oct 2027
Completion: 31 Oct 2027
Last update posted: 21 Aug 2026
Registered enrollment: 152
Registry id: NCT04858334

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.