Clinical trialNCT04172532RecruitingPhase 1/PHASE2Interventional

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

SponsorNational Cancer Institute (NCI)Enrollment92Locally Advanced Pancreatic AdenocarcinomaStage III Pancreatic Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I/II trial studies the safety, side effects and best dose of M3814 and to see how well it works when given together with radiation therapy in treating patients with pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced). M3814 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving M3814 and hypofractionated radiation therapy together may be safe, tolerable and/or more effective than radiation therapy alone in treating patients with locally advanced pancreatic cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Sarah L Davis
JHU Sidney Kimmel Comprehensive Cancer Center LAO
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

44 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

City of Hope Comprehensive Cancer Center
Duarte, California, United States
Vincent Chung
Recruiting
City of Hope at Irvine Lennar
Irvine, California, United States
Vincent Chung
Recruiting
Uci Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States
Farshid Dayyani
Recruiting
Uc Irvine Health/chao Family Comprehensive Cancer Center
Orange, California, United States
Farshid Dayyani
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Edward J. Kim
Recruiting
Uchealth University of Colorado Hospital
Aurora, Colorado, United States
Sarah L. Davis
Recruiting
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States
Michael J. Pishvaian →
Recruiting
Northwestern University
Chicago, Illinois, United States
Active, not recruiting
University of Kansas Clinical Research Center
Fairway, Kansas, United States
Anup K. Kasi Loknath Kumar
Recruiting
Haysmed
Hays, Kansas, United States
Anup K. Kasi Loknath Kumar
Recruiting
University of Kansas Cancer Center
Kansas City, Kansas, United States
Anup K. Kasi Loknath Kumar
Recruiting
Lawrence Memorial Hospital
Lawrence, Kansas, United States
Anup K. Kasi Loknath Kumar
Recruiting
the University of Kansas Cancer Center - Olathe
Olathe, Kansas, United States
Anup K. Kasi Loknath Kumar
Recruiting
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, United States
Anup K. Kasi Loknath Kumar
Recruiting
Mercy Hospital Pittsburg
Pittsburg, Kansas, United States
Suspended
Salina Regional Health Center
Salina, Kansas, United States
Anup K. Kasi Loknath Kumar
Recruiting
University of Kansas Health System Saint Francis Campus
Topeka, Kansas, United States
Anup K. Kasi Loknath Kumar
Recruiting
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, United States
Anup K. Kasi Loknath Kumar
Recruiting
University of Kentucky/markey Cancer Center
Lexington, Kentucky, United States
Withdrawn
Wayne State University/karmanos Cancer Institute
Detroit, Michigan, United States
Active, not recruiting
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, United States
Active, not recruiting
University Health Truman Medical Center
Kansas City, Missouri, United States
Anup K. Kasi Loknath Kumar
Recruiting
University of Kansas Cancer Center - North
Kansas City, Missouri, United States
Anup K. Kasi Loknath Kumar
Recruiting
University of Kansas Cancer Center - Lee'S Summit
Lee's Summit, Missouri, United States
Anup K. Kasi Loknath Kumar
Recruiting
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, Missouri, United States
Suspended
Dartmouth Hitchcock Medical Center/dartmouth Cancer Center
Lebanon, New Hampshire, United States
Active, not recruiting
Cooperman Barnabas Medical Center
Livingston, New Jersey, United States
Matthew P. Deek
Recruiting
Monmouth Medical Center
Long Branch, New Jersey, United States
Matthew P. Deek
Recruiting
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
Matthew P. Deek
Recruiting
Roswell Park Cancer Institute
Buffalo, New York, United States
Active, not recruiting
Laura and Isaac Perlmutter Cancer Center at Nyu Langone
New York, New York, United States
Active, not recruiting
Mount Sinai Hospital
New York, New York, United States
Karyn A. Goodman
Recruiting
Nyp/weill Cornell Medical Center
New York, New York, United States
Allyson J. Ocean
Recruiting
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States
Active, not recruiting
Montefiore Medical Center-Einstein Campus
The Bronx, New York, United States
Active, not recruiting
Wake Forest University at Clemmons
Clemmons, North Carolina, United States
Active, not recruiting
Wake Forest Baptist Health - Wilkes Medical Center
Wilkesboro, North Carolina, United States
Active, not recruiting
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Active, not recruiting
Upmc Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
Janie Y. Zhang
Recruiting
Vanderbilt University/ingram Cancer Center
Nashville, Tennessee, United States
Suspended

4 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Nedisertib

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 11 Jan 2021
Primary completion: 1 Aug 2027
Completion: 1 Aug 2027
Last update posted: 31 Jul 2026
Registered enrollment: 92
Registry id: NCT04172532

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.