Clinical trialNCT05057702RecruitingInterventional

Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma

SponsorUniversity of California, San FranciscoEnrollment74EpendymomaEpendymoma MalignantEpendymoma of BrainMedulloblastomaMedulloblastoma RecurrentMedulloblastoma, Childhood

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The current study will use a new treatment approach based on the molecular characteristics of each participant's tumor. The study will test the feasibility in the pilot phase of performing real-time drug screening on tissue taken during surgery in patients with relapsed medulloblastoma or ependymoma and of having a specialized tumor board assign a treatment plan based on the results of this screening and genomic sequencing. The aim of this trial is to allow every child and young adult with relapsed medulloblastoma and ependymoma to receive the most effective and least toxic therapies currently available and will pave the way for improved understanding and treatment of these tumors in the future. Moreover, if successful, it could serve as a paradigm for personalized medicine programs for other types of cancer.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Lindsay Kilburn, MD
Children's National Research Institute
Study Chair
clinicaltrials.gov ↗
Margaret Shatara, MD
Children's Minnesota
Study Chair
clinicaltrials.gov ↗
Megan Paul, MD
Rady Children's Hospital, San Diego
Study Chair
clinicaltrials.gov ↗
Robert Wechsler-Reya, PhD
Columbia University
Study Chair
clinicaltrials.gov ↗
Sabine Mueller, MD, PhD, MAS
University of California, San Francisco
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S Hospital of Los Angeles
Los Angeles, California, United States
Ashley Margol, MDTom Belle Davidson, MD
Recruiting
Rady Children'S Hospital
San Diego, California, United States
Jennifer Elster, MDMegan Paul, MD
Recruiting
University of California, San Francisco
San Francisco, California, United States
Alyssa Reddy, MDSabine Mueller, MD, PhD
Recruiting
Children'S National Hospital
Washington D.C., District of Columbia, United States
Lindsay Kilburn, MDRoger Packer, MD
Recruiting
Children'S Minnesota
Minneapolis, Minnesota, United States
Recruiting
St. Louis Children'S Hospital / Washington University in St. Louis
St Louis, Missouri, United States
Andrew Cluster, MDMohamed Abdelbaki, MD
Recruiting
Columbia University Medical Center
New York, New York, United States
James H Garvin Jr., MD
Recruiting
New York University
New York, New York, United States
Recruiting
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Cassie Kline, MD, MASJane Minturn, MD, PhD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Feb 2022
Primary completion: 31 Dec 2027
Completion: 31 Jan 2028
Last update posted: 11 Aug 2026
Registered enrollment: 74
Registry id: NCT05057702

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.